Program JKN (Jaminan Kesehatan Nasional) memberikan perubahan sangat besar dalam pelaksanaan proses bisnis dan operasional rumah sakit di Indonesia agar dapat meningkatkan taraf kesehatan dan taraf hidup penduduk Indonesia. Penelitian dilakukan melalui analisis kelayakan dan persiapan perubahan Kelas D RS Pelabuhan Palembang menjadi Kelas C di tahun 2017. Jenis penelitian kualitatif dengan metode telaah dokumen, wawancara mendalam dan Consensus Decision Making Group. Hasil Penelitian didapatkan penilaian rata-rata standar pelayanan, sumber daya manusia (SDM), peralatan, sarana dan prasarana, administrasi dan manajemen di RS Pelabuhan Palembang yaitu 73,2% . Elemen-elemen penilaian RS Pelabuhan Palembang sebagian besar memenuhi standar layak untuk menjadi kelas C. Perbaikan dan peningkatan standar yang belum terpenuhi akan dilengkapi. Kata Kunci: Kelayakan dan kesiapan, kelas rumah sakit, Jaminan Kesehatan Nasional. The JKN (National Health Insurance) program provides a biggest change in the implementation of business processes and hospital operations in Indonesia in order to improve the health and standard of living of Indonesians. The research was conducted through feasibility analysis and preparation of change of Class D RS Pelabuhan Palembang to Class C in 2017. Type of qualitative research with method of document review, in-depth interview and Consensus Decision Making Group. The result of the research is the average of service standard, human resources (HR), equipment, facillities and infrastructure, administration and management at Pelabuhan Palembang Hospital is 73,2%. Assessment Elements of Pelabuhan Hospital Palembang mostly have the proper standard to be class C. Improvements and upgrades to unmet standards will be completed. Key Word: Feasibility and Readiness, Hospital Class, National Health Insurance