Background: Self-isolation is a new approach for asymptomatic mild symtoms for COVID-19 patients. Complaints from as much as 5% of COVID-19 self-isolating patients at Puskesmas Kecamatan Kebayoran Baru should be followed up by analyzing the level of patient satisfaction and the determinant factors, as part of continuous improvement in handling COVID-19. Methodology: This research is a quantitative with cross sectional design, conducted at the Puskesmas Kecamatan Kebayoran Baru starting from June to July 2020. Data was collected by electronic survey on COVID-19 self-isolating patients. Results: The satisfaction index for self-isolating patients was 3.51. The dimensions of empathy and assurance have the highest satisfaction index (3.61), while the physical dimension is the lowest satisfaction index (3.33). Determinants of patient satisfaction include education (p value=0.018: OR=2.277), income (p value=0.000: OR=0.192), psychosocial conditions (p value=0,000: OR=3.054), and situational conditions (p value=0,000: OR=4,225). The dominant factor that affects patient satisfaction is the situational condition. Conclusion: COVID-19 sef-isolation patients satisfaction in Puskesmas Kecamatan Kebayoran Baru is categorized in the category of good quality services. The determinants of service satisfaction for COVID-19 self-isolation patients are consistent with pre- pandemic conditions on income, psychosocial, and situational variables.