Tingkat stres kerja pada perawat di Indonesia mencapai 50,9% menurut survei PPNI, mencerminkan tingginya tekanan akibat beban kerja, jam kerja panjang, dan keterbatasan sumber daya, sehingga penting untuk mendapatkan gambaran terkini mengenai tingkat stres kerja perawat dan faktor-faktor terkait. Penelitian ini bertujuan untuk mengetahui hubungan faktor pekerjaan dan faktor individu terhadap stres kerja pada perawat rumah sakit, menggunakan metode kuantitatif dengan dan pendekatan cross-sectional. Sebanyak 191 perawat yang tersebar di beberapa rumah sakit di Jabodetabek, Jawa Timur, Kalimantan Barat, Jawa Barat, Jawa Tengah, dan Kepulauan Riau menjadi responden melalui randomized sampling, dengan data dikumpulkan menggunakan Kuesioner Copenhagen Psychosocial Questionnaire-III (COPSOQ-III) dan dianalisis menggunakan uji statistik deskriptif serta Chi-square. Hasil analisis inferensial menunjukkan adanya hubungan signifikan antara stres kerja dengan status pernikahan (P-value = 0,033; OR = 1,905) dan lama masa kerja (P-value = 0,02; OR = 1,033) sebagai faktor individu, serta dengan status pekerjaan (P-value = 0,004; OR = 0,413), work-life balance (P-value = 0,001; OR = 5), dan beban kerja (P-value = 0,001; OR = 7,684) sebagai faktor pekerjaan; sementara usia, jenis kelamin, tingkat pendidikan, take home pay, dan peran dalam organisasi tidak memiliki hubungan signifikan. Disimpulkan bahwa terdapat beberapa faktor individu dan pekerjaan yang berhubungan secara signifikan dengan stres kerja pada perawat.

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The level of work stress among nurses in Indonesia reached 50,9% according to a PPNI survey, reflecting the high pressure due to heavy workload, long working hours, and limited resources, making it crucial to obtain a current overview of nurses' work stress levels and related factors. This study aimed to determine the relationship between work factors and individual factors with work stress among hospital nurses, using a quantitative method with a cross-sectional approach. A total of 191 nurses spread across several hospitals in Jabodetabek, East Java, West Kalimantan, West Java, Central Java, and Riau Islands were recruited as respondents through randomized sampling. Data were collected using the Copenhagen Psychosocial Questionnaire-III (COPSOQ-III) and analyzed using descriptive statistics and Chi-square tests. Inferential analysis results showed a significant relationship between work stress and individual factors such as marital status (P-value = 0,033; OR = 1,905) and length of service (P-value = 0,02; OR = 1,033). Furthermore, work factors including employment status (P-value = 0.004; OR = 0,413), work-life balance (P-value = 0,001; OR = 5), and workload (P-value = 0,001; OR = 7,684) also had a significant relationship with work stress. Age, gender, education level, take-home pay, and role in the organization did not show a significant relationship. It is concluded that several individual and work factors are significantly associated with work stress in nurses.