Paparan terhadap bahan kimia dan faktor fisika di lingkungan kerja manufaktur herbisida berpotensi menimbulkan risiko kesehatan serius jika tidak dilakukan pengendalian secara sistematis. Penelitian ini bertujuan untuk melakukan Health Risk Assessment (HRA) terhadap bahaya kimia dan fisika yang dihadapi oleh pekerja di area produksi, packaging, dan gudang pada industri manufaktur herbisida, dengan pendekatan berbasis Similar Exposure Group (SEG). Metode yang digunakan mengacu pada kerangka kerja ISO 31000:2018 dan praktik rekomendasi HRA dari otoritas internasional. Data diperoleh melalui dokumen pemantauan lingkungan kerja, SDS, OHSERA, dan wawancara dengan pemangku kepentingan. Risiko dinilai menggunakan matriks semi-kuantitatif berdasarkan skor likelihood dan severity, dengan validasi keparahan kesehatan merujuk pada referensi seperti ACGIH dan literatur ilmiah terkini. Hasil menunjukkan bahwa SEG Proses menghadapi risiko tinggi dari paparan Monoisopropylamine (MIPA) dan Kalium Hidroksida (KOH), sedangkan SEG Packaging dan Warehouse memiliki risiko signifikan akibat kebisingan, getaran, panas, serta uap bahan kimia volatil. Evaluasi existing control menunjukkan pengendalian belum optimal dalam menurunkan risiko ke tingkat rendah. Penelitian ini menyimpulkan bahwa penguatan pengendalian teknis dan administratif, seperti ventilasi lokal, rotasi kerja, penggunaan alat pelindung diri yang sesuai, serta pengaturan waktu kerja-istirahat, diperlukan untuk menurunkan risiko residual. Penilaian risiko berbasis SEG terbukti efektif dalam memetakan prioritas pengendalian dan memberikan dasar yang kuat untuk pengambilan keputusan K3 di industri sejenis.

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Exposure to chemical agents and physical hazards in herbicide manufacturing environments poses serious health risks if not managed systematically. This study aims to conduct a Health Risk Assessment (HRA) of chemical and physical hazards encountered by workers in the production, packaging, and warehouse areas of a herbicide manufacturing industry, using a Similar Exposure Group (SEG) approach. The methodology follows the ISO 31000:2018 risk management framework and international best practices for occupational health risk assessment. Data were obtained through environmental monitoring reports, safety data sheets (SDS), OHSERA records, and interviews with relevant stakeholders. Risks were assessed using a semi-quantitative matrix based on likelihood and severity scores, with health severity validation referring to ACGIH and recent peer-reviewed scientific literature. The findings indicate that the Process SEG faces high risks from exposure to Monoisopropylamine (MIPA) and Potassium Hydroxide (KOH), while the Packaging and Warehouse SEGs are significantly affected by noise, vibration, heat, and volatile chemical vapors. Evaluation of existing controls reveals that current measures are not sufficiently effective in reducing risks to acceptable levels. The study concludes that stronger technical and administrative controls—such as local exhaust ventilation, work rotation, appropriate use of personal protective equipment (PPE), and regulated work-rest schedules—are essential to achieve low residual risks. Risk assessment based on SEGs has proven effective in mapping control priorities and provides a solid foundation for occupational health and safety decision-making in similar industrial settings.