Pajanan kronis benzena di lingkungan kerja selalu dihubungkan dengan gangguanhematologi. Hal ini dikarenakan sistem hematologi adalah jaringan target yangpaling kritis terhadap pajanan benzena melalui rute inhalasi dan diketahui sebagaipenyebab pansitopenia. Penelitian ini bertujuan untuk menganalisis hubunganantara kadar S-PMA urin dengan leukosit pada pekerja industri sepatu informalyang terpajan benzena. Penelitian menggunakan desain cross sectional di enamindustri sepatu informal yang berada di kawasan Cibaduyut dengan jumlah sampel64 pekerja. Sampel urin dan darah diambil pada masing-masing sampel untukmenilai kadar S-PMA urin dan jumlah leukosit. Kadar S-PMA urin diukur denganmenggunakan alat LC-MS/MS dan leukosit diukur menggunakan alat AutomatedHematology Analyzer. Data karakteristik individu diperoleh melalui wawancaralangsung. Konsentrasi benzena di udara menggunakan data sekunder daripenelitian sebelumnya. Hasil penelitian menunjukkan bahwa terdapat hubunganyang signifikan antara kadar S-PMA dengan leukosit (p value: 0,048) dan kadarS-PMA urin dengan jenis pekerjaan (p value: 0,004). Sebanyak 31,3% pekerjamemiliki kadar S-PMA urin melampaui BEI ACGIH (>25 μg/g kreatinin).Semakin tinggi konsentrasi benzena di udara ruang kerja, semakin banyak pekerjayang memiliki kadar S-PMA urin >25 μg/g kreatinin. Hasil uji regresi linearganda menemukan bahwa ada kecenderungan asosiasi antara kadar S-PMA urindengan leukosit, setelah dikontrol dengan variabel jenis pekerjaan, jam kerja perhari, dan kebiasaan berolahraga. Hasil penelitian dapat disimpulkan terdapatasosiasi antara kadar S-PMA urin dengan penurunan jumlah leukosit.Kata kunci: benzena, S-phenylmercapturic acid, leukosit, industri sepatu informal

---

Benzene high exposure in working is environment always connected tohematology disorders. This is caused by hematology system is the most criticaltarget network toward benzene exposure through inhaling route. This study aimsto analyze the relation between urinary and leukocytes S-PMA level of informalshoes industrial workers exposed to benzene. This study uses cross sectionaldesign in six informal shoes industries which are located in Cibaduyut with thenumber of sample of 64 workers. Urinary and blood samples are collected on eachsample to measure urinary S-PMA level and the number of leukocytes. Urinary S-PMA level is measured using Automated Hematology Analyzer. Individualcharacteristic data are obtained through direct interview. To measure benzeneconcentration, secondary data of previous study is used. The result of the studyindicates that there is significant correlation between S-PMA level withleukocytes (p value: 0.048) and urinary S-PMA level with the type of job (p value:0.004). By 31.3% workers have urinary S-PMA level more than BEI ACGIH (>25μg/g creatinine). The higher the benzene concentration of indoor air, the moreworkers have urinary S-PMA level > 25 μg/g creatinine. The result of doublelinear regression test finds that there is association tendency between urinary andleukocytes S-PMA level, after it is controlled by type of job, time of work perday, and exercising habit variables. It can be concluded that there is associationbetween urinary S-PMA level and the number of leukocytes decrease.Keywords: benzene, S-phenylmercapturid acid, leukocytes, informal shoesindustries