BANYAKNYA WAKTU YANG DIGUNAKAN MASYARAKAT PERKOTAAN UNTUK BERAKTIVITAS DI DALAM RUANGAN DAPAT MENIMBULKAN MASALAH KESEHATAN AKIBAT KUALITAS UDARA DI DALAM RUANGAN, SEPERTI SICK BUILDING SYNDROME (SBS). TIDAK HANYA PADA PEKERJA DI PERKANTORAN, SISWA SEKOLAH JUGA BERISIKO TERHADAP SBS. PENELITIAN INI BERTUJUAN UNTUK MENGETAHUI HUBUNGAN ANTARA JUMLAH KOLONI BAKTERI DI UDARA DALAM RUANG KELAS DENGAN KEJADIAN SBS PADA SISWA DI SMAN 2 KOTA TANGERANG SELATAN. DIGUNAKAN DESAIN STUDI CROSS-SECTIONAL DENGAN VARIABEL INDEPENDEN ADALAH JUMLAH KOLONI BAKTERI; VARIABEL INDEPENDEN ADALAH KEJADIAN SBS; DAN SUHU, KELEMBABAN, PENCAHAYAAN, JENIS KELAMIN, STATUS GIZI, RIWAYAT ALERGI, RIWAYAT ASTHMA, HEWAN PELIHARAAN, KEBIASAAN MELEWATKAN SARAPAN, KEBIASAAN BEROLAHRAGA, KEBIASAAN MENGONSUMSI CAMILAN, SERTA KEBIASAAN MEROKOK ADALAH VARIABEL KOVARIAT. ANALISIS STATISTIK MENUNJUKKAN PROPORSI KEJADIAN SBS SEBESAR 59,8% DAN JUMLAH KOLONI BAKTERI TIDAK BERHUBUNGAN SIGNIFIKAN DENGAN KEJADIAN SBS. RIWAYAT ASTHMA, KEBIASAAN MELEWATKAN SARAPAN, DAN KEBIASAAN BEROLAHRAGA BERHUBUNGAN SIGNIFIKAN DENGAN KEJADIAN SBS. SISWA YANG BERADA DI KELAS DENGAN JUMLAH KOLONI BAKTERI DI UDARA< 135 KOLONI BERISIKO MENGALAMI KEJADIAN SBS 1,677 KALI LEBIH TINGGI, SETELAH DIKONTROL OLEH VARIABEL KEBIASAAN SARAPAN, KEBIASAAN BEROLAHRAGA, DAN PENCAHAYAAN. KATA KUNCI: SICK BUILDING SYNDROME, JUMLAH KOLONI BAKTERI, KUALITAS UDARA DALAM KELAS, SISWA SEKOLAH T HAS BEEN ESTIMATED THAT PEOPLE SPEND ALMOST 90% OF THEIR TIME INDOORS, MAINLY IN URBAN AREAS. THIS COULD LEAD TO HEALTH PROBLEMS CAUSED BY THE INDOOR AIR QUALITY, SUCH AS SICK BUILDING SYNDROME (SBS). BESIDES THE OFFICE WORKERS POPULATION, THERE IS ALSO INCREASING CONCERN ABOUT SBS PROBLEM IN SCHOOL STUDENT. USING CROSS-SECTIONAL STUDY DESIGN, THE ASSOCIATIONS BETWEEN TOTAL INDOOR AIR BACTERIAL COUNT IN THE CLASSROOM AND SBS IN STUDENTS OF 2 TANGERANG SELATAN HIGH SCHOOL WAS INVESTIGATED. WE DETERMINED THE TOTAL BACTERIAL COUNT AS DEPENDENT VARIABLE; SBS INCIDENCE AS INDEPENDENT VARIABEL; CLASSROOM TEMPERATURE, HUMIDITY, AND LIGHTING INTENSITY AS ENVIRONMENTAL COVARIATE VARIABLES; AND GENDER, NUTRITIONAL STATUS, HISTORY OF ALLERGY AND ASTHMA; PET OWNERSHIP; SKIPPING BREAKFAST; SNACKING HABIT; EXERCISING HABIT; AND SMOKING HABIT AS INDIVIDUAL COVARIATE VARIABLES. STATISTICAL ANALYSIS RESULTS SHOWED A HIGH PROPORTION OF SBS (59,8%) AND THE TOTAL INDOOR AIR BACTERIAL COUNT IS NOT SIGNIFICANTLY ASSOCIATED WITH SBS. HISTORY OF ASTHMA, SKIPPING BREAKFAST, AND EXERCISING HABIT ARE SIGNIFICANTLY ASSOCIATED WITH SBS. STUDENTS WHO ARE STUDYING IN CLASSROOM WITH TOTAL BACTERIAL COUNT < 135 COLONY HAVE 1,677 TIMES HIGHER RISK OF EXPERIENCING SBS THAN THE NON- RISK GROUP. KEYWORDS: SICK BUILDING SYNDROME, TOTAL INDOOR AIR BACTERIAL COUNT, CLASSROOM AIR QUALITY, SCHOOL STUDENTS