Menurut World Health Organization (WHO), sekitar 12,2 juta kasus baru stroke terjadi setiap tahun secara global, dan lebih dari 6,5 juta orang meninggal akibat stroke setiap tahunnya.  Di Indonesia, berdasarkan hasil Survei Kesehatan Indonesia (SKI) tahun 2023, prevalensi stroke pada penduduk usia ≥15 tahun tercatat sebesar 1,32%, dengan proporsi lebih tinggi pada laki-laki dan kelompok usia lanjut. Tujuan penelitian ini untuk mengetahui hubungan antara hipertensi, diabetes melitus dengan kejadian stroke pada penduduk DKI Jakarta. Penelitian ini merupakan studi analitik dengan pendekatan cross-sectional menggunakan data SKI 2023. Analisis dilakukan dengan regresi logistik multivariat dengan dua pendekatan yaitu, variabel hipertensi self-reported dan menggunakan hasil pengukuran tekanan darah pada 8.942 responden menggunakan pendekatan non-weighted pada multivariat. Hasil multivariat baik pendekatan self- report maupun hasil pengukuran hipertensi menjadi faktor risiko terkuat penyebab stroke dengan (OR = 13,09; 95% CI: 7,06–24,28; p < 0,001) dan (OR = 6,13; 95% CI: 2,62–14,31; p < 0,001), Laki-laki memiliki risiko stroke 2 kali lipat dibanding perempuan (p = 0,005). Usia ≥60 tahun memiliki OR tertinggi yaitu 9,09 (95% CI: 3,38–24,44; p < 0,001). Diabetes hanya signifikan dalam model pengukuran dengan OR = 6,59 (p < 0,001), untuk aktivitas fisik terbukti protektif. Dapat disimpulkan hipertensi baik berdasarkan self-report maupun hasil pengukuran merupakan prediktor kuat kejadian stroke. Aktivitas fisik memiliki efek protektif yang signifikan. Penggunaan data tekanan darah terukur memberikan estimasi risiko yang lebih konservatif namun stabil. Hasil ini menegaskan pentingnya deteksi dini hipertensi dan promosi aktivitas fisik dalam strategi pencegahan stroke.

According to the World Health Organization (WHO), approximately 12.2 million new cases of stroke occur globally each year, with over 6.5 million deaths attributed to stroke annually. In Indonesia, based on the 2023 Indonesian Health Survey (SKI), the prevalence of stroke among individuals aged ≥15 years was recorded at 1.32%, with higher proportions among males and the elderly population. This study aimed to determine the association between hypertension, diabetes mellitus, and stroke among residents of DKI Jakarta. This was an analytical cross-sectional study using SKI 2023 data, involving 8,942 respondents. Multivariate logistic regression was conducted using two approaches: self-reported hypertension and measured blood pressure. Both models were analyzed without weighting. The results showed that hypertension was the strongest risk factor for stroke, both in the self-reported model (OR = 13.09; 95% CI: 7.06–24.28; p < 0.001) and the measured blood pressure model (OR = 6.13; 95% CI: 2.62–14.31; p < 0.001). Males had twice the risk of stroke compared to females (p = 0.005). Individuals aged ≥60 years had the highest risk (OR = 9.09; 95% CI: 3.38–24.44; p < 0.001). Diabetes mellitus was significantly associated with stroke only in the model using measured blood pressure (OR = 6.59; p < 0.001). Physical activity was found to have a significant protective effect. In conclusion, hypertension—both self-reported and based on measured blood pressure is a strong predictor of stroke. Physical activity plays a significant protective role. Using objectively measured blood pressure yields a more conservative but stable risk estimate. These findings underscore the importance of early hypertension detection and the promotion of physical activity in stroke prevention strategies.