Abstrak: Merokok berbahaya bagi perokok aktif maupun perokok pasif (Aditama, 2001).Asap rokok mengandung nikotin yang dapat memicu aktivitas kelenjar tiroid padamanusia (Utiger, 1998). Wanita lebih rentan mengalami hipertiroid (Greenspanand Baxter, 1994). Penelitian ini bertujuan untuk mengetahui hubungan antarastatus merokok dengan kejadian hipertiroid pada pasien wanita usia subur diKlinik Balai Litbang GAKI Magelang tahun 2013-2014. Penelitian dilakukandengan disain kasus-kontrol. Penelitian melibatkan 51 responden pasien wanitausia subur penderita hipertiroid dan 102 responden pasien wanita usia suburdengan fungsi tiroid normal (eutiroid). Pengumpulan data dilakukan pada statusmerokok, umur, penggunaan kontrasepsi hormonal, melahirkan 1 tahun terakhir,tingkat stres, dan kebiasaan penggunaan garam beriodium rumah tanggaresponden. Data dianalisa menggunakan uji regresi logistik. Pasien wanita usiasubur terpajan asap rokok baik perokok aktif atau pasif berisiko mengalamihipertiroid 2,05 kali dari risiko pasien wanita usia subur di Klinik Balai LitbangGAKI Magelang setelah dikontrol variabel kontrasepsi hormonal dan tingkatstres. Menggunakan kontrasepsi hormonal menurunkan risiko hipertiroid,sedangkan stres berat meningkatkan risiko hipertiroid. Wanita usia suburhendaknya menghindari pajanan asap rokok dan melakukan manajemen stresuntuk mengurangi faktor risiko hipertiroid.
Kata kunci : kasus-kontrol, status merokok, hipertiroid, wanita usia subur,

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Smoking is harmful to the active smokers and passive smokers (Aditama, 2001).Tobacco smoke contains nicotine, chemical that are known can leadhyperthyroidism in human (Utiger, 1998). This study aimed to determine therelationship between smoking status on hyperthyroidism in patients ofchildbearing age women in the Clinic of IDD (Iodine Deficiency Disorders)Research Center, Magelang in 2013-2014. The study was conducted with a case-control design. The study involved 51 childbearing-age women patients withhyperthyroidism patients and 102 childbearing-age women patients with normalthyroid function (euthyroid). Data collection was conducted on smoking status,age, hormonal contraceptive use, giving birth in the past one year, the level ofstress, and the habits of the use of iodized salt in the household. Data wereanalyzed using logistic regression. Chiilbearing-age women patients who wereactive/passive smokers at risk of hyperthyroidism 2.05 times the risk ofchildbearing-age women patients in the Clinic of Iodine Deficiency Disorders(IDD) Research Center, Magelang after controlled by hormonal contraceptivesand stress levels variables. Use of hormonal contraceptives reduce the risk ofhyperthyroidism, whereas severe stress increases the risk of hyperthyroidism.Childbearing-age women should avoid exposure to cigarette smoke and do stressmanagement to reduce risk factors for hyperthyroidism.
Keywords : case-control, smoking status, hyperthyroidism, childbearing agewomen