Latar belakang: Pelayanan kesehatan merupakan hak dasar masyarakat yang wajib diselenggarakan secara efektif dan efisien oleh rumah sakit, termasuk dalam hal pengelolaan persediaan farmasi. Rumah Sakit Kanker Dharmais sebagai Rumah Sakit Pusat Kanker Nasional memiliki tantangan dalam menjaga ketersediaan obat kanker yang bernilai tinggi dan berisiko kritis. Berdasarkan data capaian indikator Rasio Beban Persediaan Farmasi terhadap Pendapatan Operasional pada periode September–Desember 2024, diketahui bahwa nilai rasio tersebut tidak mencapai target yang ditetapkan Kementerian Kesehatan. Hal ini mengindikasikan perlunya evaluasi terhadap sistem pengendalian persediaan farmasi. Tujuan: Penelitian ini bertujuan untuk mengevaluasi efektivitas analisis ABC-VEN dalam pengendalian persediaan farmasi di RSK Dharmais. Metode: Penelitian menggunakan desain operational research dengan pendekatan campuran kualitatif dan kuantitatif. Data diperoleh melalui wawancara mendalam kepada informan kunci serta data sekunder dari SIMRS dan laporan rumah sakit tahun 2024. Analisis dilakukan terhadap seluruh item obat yang termasuk dalam formularium rumah sakit. Hasil: Hasil penelitian menunjukkan bahwa pada pengelompokan ABC, kelompok A berdasarkan jumlah pemakaian terdiri dari 79 item (6,11%) yang menyumbang 69,93% nilai penggunaan, dan berdasarkan nilai investasi terdiri dari 107 item (8,27%) dengan kontribusi 69,97% dari total investasi. Kelompok obat esensial mendominasi dengan proporsi 79,60% (1.030 item), diikuti oleh kelompok non-esensial 11,90% dan vital 8,50%. Kombinasi analisis ABC-VEN menunjukkan bahwa sebagian besar obat prioritas tinggi adalah obat kanker. Simulasi ITOR menunjukkan bahwa tingkat perputaran persediaan dapat ditingkatkan, sehingga manajemen stok menjadi lebih efisien dan adaptif terhadap kebutuhan klinis. Kesimpulan: Analisis ABC-VEN terbukti efektif dalam mengidentifikasi prioritas pengendalian dan optimalisasi pengelolaan obat kanker di RSK Dharmais, serta berkontribusi dalam peningkatan efisiensi logistik farmasi rumah sakit.Background: Healthcare services are a fundamental right of every citizen and must be delivered effectively and efficiently by hospitals, including the management of pharmaceutical inventories. Dharmais Cancer Hospital, as the National Cancer Center Hospital in Indonesia, faces significant challenges in ensuring the availability of high-cost and critically important cancer drugs. Based on the performance indicator of the Pharmaceutical Inventory Cost Ratio to Operational Revenue for the period of September to December 2024, it was found that the ratio consistently failed to meet the targets set by the Ministry of Health. This condition highlights the need for an evaluation of the pharmaceutical inventory control system. Purpose: This study aims to evaluate the effectiveness of the ABC-VEN analysis in controlling pharmaceutical inventory at Dharmais Cancer Hospital. Method: This research employs an operational research design with a mixed-method approach, incorporating both qualitative and quantitative data. Primary data were collected through in-depth interviews with key informants, while secondary data were obtained from the Hospital Information Management System (SIMRS) and institutional reports from the year 2024. The analysis was conducted on all pharmaceutical items listed in the hospital formulary. Results: The results show that in the ABC classification, Class A drugs based on usage volume included 79 items (6.11%) which accounted for 69.93% of total drug usage value, while based on investment value, 107 items (8.27%) represented 69.97% of total inventory value. Essential drugs dominated the VEN classification with 79.60% (1,030 items), followed by non-essential drugs at 11.90% and vital drugs at 8.50%. The ABC-VEN matrix revealed that most high-priority drugs were cancer medications. ITOR simulation results indicated that inventory turnover could be significantly improved, leading to more efficient and responsive stock management aligned with real clinical needs. Conclusion: ABC-VEN analysis proved effective in identifying inventory control priorities and optimizing the management of cancer drugs at Dharmais Cancer Hospital, thereby enhancing pharmaceutical logistics efficiency.