Penelitian ini bertujuan mengetahui gambaran faktor-faktor yang berhubungan dengan perubahan kadar kolinesterase pada petani sayur di Kelurahan Lingkar Selatan Kecamatan Jambi Selatan tahun 2011. Penelitian merupakan studi deskriptif analitik dengan menggunakan metode cross sectional dengan jumlah populasi sebanyak 104 petani dimana jumlah sampel sebanyak 68 petani . Hasil uji  didapatkan hubungan yang bermakna antara lama penyemprotan (p-value = 0,009), frekuensi penyemprotan (p-value = 0,019),  lama kerja sebagai penyemprot (p-value = 0,018), kelengkapan APD  (p-value = 0,039), umur (p-value = 0,004), pengetahuan (p-value =0,018), dan perilaku  (p-value = 0,038), dengan perubahan kadar kolinesterase. Agar petani tidak terpajan perlu dilakukan penyuluhan, bimbingan, pembinaan, pengawasanan pemantauan lintas sektoral. Kata kunci: xi Kolinesterase, perubahan kadar,petani sayur

 This study aims to know the description of the factors associated with changes in cholinesterase levels on vegetable farmers in the South Rim Village South Subdistrict Jambi in 2011. The research is analytical descriptive study using cross-sectional with a population of as many as 104 farmers where the number of samples as many as 68 farmers. The test results found a significant association between duration of spraying (p-value = 0.009), frequency of spraying (p-value = 0.019), length of employment as a spray (p-value = 0.018), completeness of PPE (p-value = 0.039), age (p-value = 0.004), knowledge (p-value = 0.018), and behavior (p-value = 0.038), with changes in cholinesterase levels. In order to do farmers not exposed to counseling, guidance, coaching, supervision of cross-sectoral monitoring. Key words: Cholinesterase, changing levels, vegetable farmers