Compassion Fatigue (CF) merupakan kondisi kelelahan emosional dan stres yang direpresentasikan oleh Burnout (BO) dan Secondary Traumatic Stress (STS). Mahasiswa Profesi Ners berpotensi mengalami CF melalui pendidikan praktik klinik intensif pada berbagai setting pelayanan kesehatan. Namun, di Indonesia penelitian mengenai CF pada Mahasiswa Profesi Ners masih sangat terbatas. Penelitian ini bertujuan untuk menganalisis distribusi tingkat BO dan STS, serta hubungan antara faktor lingkungan kerja dan tugas atau pekerjaan praktik klinik, faktor klien atau pasien, dan faktor karakteristik individu dengan masing-masing BO dan STS pada Mahasiswa Profesi Ners Universitas Indonesia Tahun 2026. Penelitian ini menggunakan desain kuantitatif dengan pendekatan cross-sectional. Pengambilan sampel dilakukan dengan teknik total sampling pada Mahasiswa Profesi Ners Universitas Indonesia Tahun 2026 yang memenuhi kriteria inklusi, dengan jumlah responden akhir sebanyak 41 orang. Data dikumpulkan menggunakan instrumen baku seperti Professional Quality of Life Scale versi 5 (ProQOL V), Connor-Davidson Resilience Scale versi 10 item (CD-RISC-10), General Self-Efficacy Scale (GSES), dan Multidimensional Scale of Perceived Social Support (MSPSS). Hasil penelitian menemukan bahwa pada distribusi tingkat BO relatif seimbang antara kategori BO yang lebih rendah (51,2%) dan kategori BO yang lebih yang lebih tinggi (48,8%). Selain itu, pada distribusi tingkat STS sebagian besar responden (82,9%) berada pada kategori sedang. Keduanya menunjukan keberadaan BO dan STS sebagai representasi CF pada Mahasiswa Profesi Ners Universitas Indonesia Tahun 2026. Ditemukan juga faktor yang berhubungan signifikan dengan BO, yaitu faktor klien atau pasien berupa frekuensi pengalaman menyaksikan atau merawat klien atau pasien yang sekarat atau meninggal dunia (p = 0,045; OR = 3,792) dan faktor karakteristik individu berupa lama praktik klinik (p = 0,023; OR = 4,643) serta resiliensi psikologis (p = 0,010; OR = 5,833). Sementara itu, tidak ditemukan hubungan yang signifikan secara statistik antara ketiga faktor dengan STS.

Compassion Fatigue (CF) is a condition of emotional exhaustion and stress represented by Burnout (BO) and Secondary Traumatic Stress (STS). Nursing Professional Program Students are potentially at risk of experiencing CF through intensive clinical practice education across various healthcare settings. However, in Indonesia, research on CF among Nursing Professional Program Students remains very limited. This study aims to analyze the distribution levels of BO and STS, as well as the relationships between work environment and clinical practice task or job factors, client or patient factors, and individual characteristic factors with BO and STS, respectively, among Nursing Professional Program students at Universitas Indonesia in 2026. This study employed a quantitative design with a cross-sectional approach. Sampling was conducted using a total sampling technique among Nursing Professional Program students at Universitas Indonesia in 2026 who met the inclusion criteria, resulting in a final sample of 41 respondents. Data were collected using standardized instruments, namely the Professional Quality of Life Scale version 5 (ProQOL V), the Connor-Davidson Resilience Scale 10 item version (CD-RISC-10), the General Self-Efficacy Scale (GSES), and the Multidimensional Scale of Perceived Social Support (MSPSS). The results found that the distribution of BO levels was relatively balanced between the lower BO category (51.2%) and the higher BO category (48.8%). In addition, the distribution of STS levels showed that the majority of respondents (82.9%) fell into the moderate category. Both findings indicate the presence of BO and STS as representations of CF among Nursing Professional Program students at Universitas Indonesia in 2026. The study also found factors significantly associated with BO, namely the client or patient factor in the form of frequency of experience witnessing or caring for dying or deceased clients or patients (p = 0.045; OR = 3.792), and individual characteristic factors in the form of length of clinical practice (p = 0.023; OR = 4.643) and psychological resilience (p = 0.010; OR = 5.833). Meanwhile, no statistically significant relationship was found between the three factors and STS.