Malaria masih menjadi masalah kesehatan masyarakat di wilayah timur Indonesia. Penelitian ini bertujuan menganalisis faktor-faktor yang berhubungan dengan kejadian malaria di Tanah Papua berdasarkan data Survei Kesehatan Indonesia (SKI) 2023. Penelitian ini menggunakan desain cross-sectional analitik dengan pendekatan kasus dan non-kasus. Data berasal dari SKI 2023 yang mencakup 37.036 responden dari wilayah Papua. Kasus didefinisikan sebagai individu yang mengalami malaria dalam

Malaria remains a public health issue in eastern Indonesia. This study aimed to analyze factors associated with malaria incidence in Tanah Papua based on data from the 2023 Indonesia Health Survey (SKI 2023). The study employed an analytical cross-sectional design with a case and non-case approach. The data were drawn from SKI 2023 and included 37,036 respondents from the Papua region. A malaria case was defined as an individual who had experienced malaria within the past month. Analyses were conducted using univariate, bivariate, and multivariate methods with logistic regression to calculate the Prevalence Odds Ratio (POR). The malaria prevalence was recorded at 4.80%. Factors significantly associated with malaria incidence included education level, type of occupation, household size, and interactions between age and sex, ventilation and bed net use, as well as age and mosquito repellent use. The strongest association was observed in the interaction between age and sex, in which males aged over 46 years had 2.85 times higher odds of having malaria compared to female children under five years. Malaria incidence in Tanah Papua remains high and is influenced by a complex interplay of individual characteristics and environmental factors, including preventive behaviors.

Prevalensi Sifilis menurut data STBP Kemenkes Tahun 2011 pada 7 populasi kunci adalah sebesar 6% dimana prevalensi Sifilis tertinggi ditemukan pada Transgender Waria (25%) kemudian diikuti WPSL (10%), LSL (9%), WBP (5%), Pria Potensial Risti (4%), WPSTL (3%) dan Penasun (2%). Sifilis pada Transgender Waria meningkat 1% dari 27% pada STBP 2007 menjadi 28% pada STBP 2011 di kota yang sama. Faktor- faktor yang diduga berhubungan dengan infeksi Sifilis pada Transgender Waria antara lain : Umur, Tingkat Pendidikan, Penggunaan kondom, Penggunaan Napza Suntik, Penggunaan Hormon Suntik Silikon, Status HIV, Datang ke Layanan Klinik IMS, Konsumsi Alkohol dan Lama melakukan hubungan Seks Komersial dengan mendapat imbalan. Tujuan : Mengetahui hubungan faktor ?faktor terhadap infeksi Sifilis pada Transgender Waria. Desain studi Cross Sectional dengan sampel sebanyak 1.089 Waria secara acak dan berasal dari 5 kota besar di Indonesia melalui metode wawancara, Diagnosis Laboratorium Sifilis dilakukan dengan TPHA dan RPR. Hasil : Prevalensi Sifilis pada Transgender Waria di 5 Kota sebesar 25,25%, Faktor yang berhubungan signifikan adalah Status HIV(p=0,000), PR =2,28 (95% CI 1,78-2,92) kemudian Umur >31 tahun (p=0,000) ,PR= 1,76 (95% CI 1,36- 2,28) dan Penggunaan Hormon Suntik Silikon (p=0,012) PR=1,37 (95% CI 1,07-1,76), Tingkat pendidikan, Lamanya melakukan hubungan seks komersial dengan imbalan, Penggunaan Kondom, Konsumsi Napza Suntik, Konsumsi Alkohol dan Akses ke Layanan IMS tidak berhubungan. Kesimpulan : Faktor biologis Status HIV memiliki hubungan yang kuat PR =2,28 (95% CI 1,78-2,92)dengan Kejadian Sifilis pada Kelompok Transgender Waria di 5 Kota besar di Indonesia.

 The prevalence of syphilis according to MOH- IBBS 2007 was found at 6% in the High Risk Population. Highest prevalence was found in Transvestite (25%) followed by Direct Female Sex Worker (10%), MSM (9%), PLT (5%), High Risk Men's (4%), Non Direct Female Sex Worker (3%) and IDU (2%). Syphilis Prevalens among Transvestite increased 1% from 27% to 28 % (2007 to 2011 in the same city). Factors associated with syphilis infection in Transvestite are Age, level of Education, Condom use, Drug Injection use, Use of Silicon Injections, HIV Status, Access to STI Service Clinic, Alcohol consumption and The duration of engaging in commercial sex. Purpose: Knowing associated factors of syphilis infection on Transvestite. Design Cross sectional study with a sample of 1089 randomly Transvestite and derived from the 5 major cities in Indonesia through the interview method and Laboratory diagnosis of syphilis is performed by TPHA and RPR. Results: The prevalence of syphilis in Transvestite in 5 Cities is 25.25% and significant factors related are HIV status (p = 0.000), PR =2,28 (95% CI 1,78-2,92), Age > 31 years (p=0,000) ,PR= 1,76 (95% CI 1,36-2,28), Use of Silicon Injection Hormone p=0,012) PR=1,37 (95% CI 1,07-1,76), Low educational level, The duration of engaging in commercial sex, Condom Use, Drug Injection, Alcohol consumption and Access to STI Service Clinic are not significant related. Conclusion: HIV Status as a biological factors have a strong relation with Syphilis incidence in Transvestite group population within 5 major cities in Indonesia PR =2,28 (95% CI 1,78-2,92).