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Immortal time bias in phamacoepidemiology

by Samy Suissa

AJE Vol.167, No.4

Baltimore : Johns Hopkins Bloomberg School of Public Health, 2008

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Immeasurable time bias in observational studies of drug effects on mortality

Samy Suissa

AJE Vol.168, No.3

Oxford : Oxford University Press, 2008

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Correcting for Lead Time and Length Bias in Estimating the Effect of Screen Detection on Cancer Survival

Stephen W. Duffy ... [et al.]

Abstrak: Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period. Assuming two latent categories of tumors, one of which is more prone to screen detection and correspondingly less prone to death from the cancer in question, the authors have developed a strategy of sensitivity analysis for various magnitudes of length bias. Here they demonstrate these methods using a series of 25,962 breast cancer cases (1988-2004) from the West Midlands, United Kingdom.

AJE Vol.168, No.1

[s.l.] : [s.n.] : 2008

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