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Penelitian ini dilakukan untuk mengetahui peran penggunaan obat antihiperlipidemia terhadap penurunan kadar kolesterol total.Penelitian analitik dengan rancangan Nested Case Control ini memanfaatkan data sekunder dari studi prospektif CARES (Cardiovascular Risk Estimation and Screening) tahun 2000 pada kelompok Crystal Club dan data primer untuk melengkapi kekurangan pada data. Dengan menggunakan total error laboratorium Prodia sebesar 10% maka kasus adalah mereka yang mengalami penurunan kadar kolesterol total 10% atau lebih selama kurang lebih satu bulan sedangkan kontrol adalah yang mengalami penurunan kadar kolesterol total kurang dari 10% atau mengalami peningkatan selama kurang lebih satu bulan juga.Dari 227 responden pada awal pemeriksaan terdapat 83,7% yang memiliki kadar kolesterol total > 200 mg/dl. Pada pemeriksaan yang kedua jumlah responden berkurang menjadi 191 responden. Untuk mengetahui peran penggunaan obat antihiperlipidemia dilakukan wawancara kembali. Dari 82 responden berhasil diwawancarai. Dari 82 responden 44 responden tidak menggunakan obat dan 38 responden menggunakan obat anttbiperlipidemia. Rata-rata penurunan terbesar diperoleh pada mereka yang menggunakan obat jenis atorvastatin yaitu sebesar 23,19%.Hasil penelitian menunjukkan bahwa penurunan kadar kolesterol total > 10% berhubungan dengan menggunakan obat antihiperlipidemia (OR = 5,91, 95% Cl 2,07 ; 16,88) dan pendidikan tinggi (OR = 5,28, 95% CI 1,59 ; 17,54) . Probabilitas penurunan kadar kolesterol total tertinggi pada mereka yang menggunakan obat antihiperlipidemia dan berpendidikan tinggi (75%). Bila dilihat dari jenis obat yang dikonsumsi maka penurunan kadar kolesterol total > 10% berhubungan dengan penggunaan obat jenis lain (OR = 1,35, 95% CI 0,28 ; 6,54), obat jenis statin lain (OR = 4,58, 95% CI 0,80 ; 26,04) dan obat jenis atorvastatin (OR = 19,93, 95% CI 4,21 ; 94,43) serta pendidikan tinggi (OR = 5,31, 95% Cl 1,40 ; 20,25). Probabilitas penurunan kadar kolesterol total tertinggi pada mereka yang menggunakan obat jenis atorvastatin dan berpendidikan tinggi (91%). Dan bila dilihat dari jumlah obat yang digunakan maka penurunan kadar kolesterol total berhubungan dengan penggunaan obat kurang dari 30 butir (OR = 3,36, 95% CI 0,75 ; 15,01) dan penggunaan obat sebanyak 30 butir selama satu bulan (OR = 7,47, 95% CI 2,33 ; 23,91) serta pendidikan tinggi (OR = 5,15, 95% CI 1,53 ; 17,30). Probabilitas penurunan kadar kolesterol total tertinggi pads mereka yang menggunakan obat antihiperlipidemia sebanyak 30 butir dan berpendidikan tinggi (80%).Berdasarkan hasil penelitian maka perlu dilakukan penelitian leblh lanjut untuk melihat efek dari penggunaan obat antihiperlipidemia terhadap penurunan risiko penyakit jantung koroner maupun risiko penyakit kardiovaskular lainnya.Daftar Pustaka : 64 (I982-2002)
The Role of Using Antihyperlipidernic on The Lowering of Total Cholesterol Level.The objective of this study is to examine the role of using antlhyperlipidemic on the lowering of total cholesterol level.This study is an analytical study with nested case control designed by using secondary data from prospective CARES (Cardiovascular Risk Estimation and Screening) study in 2000 and by using primary data to complete it. By using 10% total error from Prodia laboratory, the cases is people who get >10% decrease of total cholesterol level in one month, and control is people who get <10% decrease or increase of total cholesterol level as the same time.From 227 respondents in the early examination there are 83.7% who have X200 mg/dl total cholesterol level. In the second examination the number of respondents were decreased to 191 respondents. In order to examine the role of antihyperlipidemic, re-interview was conducted to 82 respondents. In which 38 respondents used the drugs whereas 44 didn't. Respondents who used atorvastatin had highest decrease of cholesterol level (23.19% on average).The result indicates that X10% decrease of total cholesterol level was related to the using of antihyperlipidemic (OR = 5.91, 95% CI 2.07 ; 16.88) and high educational level (OR - 5.28, 95% CI L59 ; 17.54). The highest probability of the decrease of total cholesterol level is people who take antihyperlipidemic and have high educational level (75%). According to the variety of drugs that being consumed, ?l0% decrease of total cholesterol level related to other drugs (OR = 1.35, 95% CI 0.28 ; 6.54), other statin drugs (OR = 4.58, 95% CI 0.80 ; 26.04), atorvastatin (OR = 19.93, 95% CI 4.21 ; 94.43), and people with high educational level (OR = 5.31, 95% CI 1.40 ; 20.25). The highest probability of decrease of total cholesterol level is people who take atorvastatin and high educational level (91%). According to the number of drug that being consumed, ?10% decrease of total cholesterol level was related to the use of < 30 pills antihyperlipidemic in one month (OR = 3.36, 95% CI 0.75 ; 15.01), the use of 30 pills in one month (OR = 7.47, 95% CI 2.33 ; 23.91), and who have high educational level (OR = 5,15, 95% CI 1,53 ; 17,30). The highest probability of the decrease of total cholesterol level is people who take 30 pills antihyperlipidemic in one month and high educational level (80%).Based on these results, it is very important to conduct several follow-up studies to confirm the effect of antihyperlipidemic on the decrease of coronary heart disease's risk or other cardiovascular diseases.References : 64 (1982-2002)
Metode: Penelitian ini menggunakan metode penelitian kuantitatif dengan desain studi eksperimen. Jumlah sampel penelitian ini sebanyak 64 sampel air limbah terolah pada outlet di Instalasi Pengolahan Air Limbah Puksesmas X Jakarta. Data kadar total coliform didapatkan dari hasil pemeriksaaan sampel di laboratorium terakreditasi. Sinar ultraviolet menggunakan lampu TL UVC merk Philips dengan daya 15 watt.
Hasil: Berdasarkan rata-rata persentase penurunan kadar Total Coliform pada sampel setelah mendapatkan perlakuan dengan sinar ultarviolet setelah 2 menit sebesar 10%, setelah 4 menit sebesar 21,25%, setelah 6 menit sebesar 26,75%, setelah 8 menit sebesar 42,5%, setelah 10 menit sebesar 58,75%. Persentase penurunan total coliform setelah 10 menit penyinaran memiliki efektifitas yang paling tinggi. Dari uji korelasi diketahui bahwa ada hubungan yang kuat antara lama penyinaran ultraviolet dengan penurunan total Coliform.
Background: This study aims to determine the effective time to reduce total coliform levels by using ultraviolet light in treated wastewater at the outlet of the Wastewater Treatment Plant of Health Center X in Jakarta in 2022.
Methods: This research uses quantitative research methods with an experimental study design. The number of samples in this study were 64 samples of treated wastewater at the outlets of the Wastewater Treatment Plant of Public Health Center X Jakarta. Data on total coliform levels were obtained from the results of examination of samples in an accredited laboratory. Ultraviolet light using Philips brand TL UVC lamp with 15 watts of power.
Results: Based on the average percentage decrease in Total Coliform levels in the sample after receiving treatment with ultraviolet light after 2 minutes by 10%, after 4 minutes by 21.25%, after 6 minutes by 26.75%, after 8 minutes by 42.5 %, after 10 minutes of 58.75%. The percentage of total coliform decrease after 10 minutes of irradiation had the highest effectiveness. From the correlation test, it is known that there is a strong relationship between the duration of ultraviolet irradiation and the decrease in total Coliform.