Ditemukan 4 dokumen yang sesuai dengan query :: Simpan CSV
Kwok Leung Ong, Matthew A. Allison, Bernard M.Y. Cheung, Ben J. Wu, Philip J. Barter, Kerry-Anne Rye
Abstrak:
C-reactive protein (CRP) is a well-known biomarker of systemic inflammation and cardiovascular disease. We investigated the trends in prevalence of elevated CRP levels (>3.0 mg/L) in a general population of US adults. Data from 27,214 subjects aged ≥20 years in the 1999-2010 National Health and Nutrition Examination Survey were analyzed. After adjustment for age, sex, race/ethnicity, body mass index (weight (kg)/height (m)(2)), and medications for lowering blood pressure, glucose, and lipids, the prevalence of elevated CRP decreased significantly from 36.7% in 1999-2002 to 32.0% in 2007-2010, corresponding to a decrease in mean CRP level from 1.92 to 1.66 mg/L (both P < 0.001). The trend remained significant after additional adjustment for several traditional cardiovascular risk factors and use of different medications, including statins. However, the decreasing trends were attenuated after additional adjustment for total bilirubin (P = 0.08 and 0.02), which increased from 0.62 to 0.73 mg/dL over 12 years (P < 0.001). The decreasing trend of CRP levels is encouraging and may be related to the increase in total bilirubin levels. Such trends may be explained in part by the increasing use of medications such as statins, which can increase bilirubin levels and decrease CRP levels.
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AJE Vol.177, No.12
Oxford : Oxford University Press, 2013
Indeks Artikel Jurnal-Majalah Pusat Informasi Kesehatan Masyarakat
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Seamus P. Whelton, Probal Roy, Brad C. Astor, Lin Zhang, Ron C. Hoogeveen, Christie M. Ballantyne, Josef Coresh
AJE Vol.178, No.7
Oxford : Oxford University Press, 2013
Indeks Artikel Jurnal-Majalah Pusat Informasi Kesehatan Masyarakat
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Amy C. Cohn, Lucy Busija, Liubov D. Robman, Peter N. Dimitrov, Mary Varsamidis, Lyndell L. Lim, Paul N. Baird, Robyn H. Guymer
Abstrak:
In this study, we examined the relationship between exposure to siblings and 1) the risk of age-related macular degeneration (AMD) and 2) C-reactive protein levels. We retrospectively analyzed pooled cross-sectional data from 2 studies: the Cardiovascular Health and Age-Related Maculopathy Study (2001-2002) and the Age-Related Maculopathy Statin Study (2004-2006). Associations between number of siblings and AMD were assessed by using multinomial logistic regression. Associations between number of siblings and C-reactive protein levels were examined by using a generalized linear model for γ distribution. A higher number of younger siblings was associated with significantly lower odds of early AMD in those with a family history of AMD (odds ratio = 0.2, 95% confidence interval: 0.1, 0.8) (P = 0.022) but was unrelated to AMD for those who had no family history of the disease (odds ratio = 1.0, 95% confidence interval: 0.9, 1.2) (P = 0.874). A higher number of younger siblings correlated with lower C-reactive protein levels (β = -0.19, 95% confidence interval: -0.38, -0.01) (P = 0.036). This supports the theory that immune modulation contributes to AMD pathogenesis and suggests that exposure to younger siblings might be protective when there is a family history of AMD.
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AJE Vol.177, No.9
Oxford : Oxford University Press, 2013
Indeks Artikel Jurnal-Majalah Pusat Informasi Kesehatan Masyarakat
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Jasrida Yunita; Pembimbing: Ratu Ayu Dewi Sartika; Kopromotor: Ratna Djuwita Hatma, Widjaja Lukito; Penguji: Sudijanto Kamso, Kusharisupeni Djokosujono, Ekowati Rahajeng, Sugeng Eko Irianto, Purwita Wijaya Laksmi
Abstrak:
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Penuaan populasi manusia di dunia dianggap sebagai masalah kesehatan masyarakat karena sering diikuti penurunan fungsi tubuh yang berdampak pada risiko penyakit. Peradangan kronis yang ditandai dengan peningkatan konsentrasi High Sensitivity C- reactive protein (hs-CRP) dianggap sebagai faktor kunci yang berkontribusi terhadap penuaan. Peradangan juga erat kaitannya dengan obesitas. Tujuan penelitian ini adalah untuk menganalisis perubahan lingkar pinggang (LP) dan rasio lingkar pinggang tinggi badan (RLPTB) terhadap konsentrasi hs-CRP dari pralansia hingga lansia follow up 7 di Indonesia. Studi ini merupakan studi kohor prospektif dengan memanfaatkan data Indonesian Family Life Survey tahun 2007-2014. Populasi target adalah individu usia pralansia (53-59 tahun) yang diikuti sampai lansia (usia 60-66 tahun) dengan jumlah sample yang eligible adalah 348 sampel sesuai dengan kriteria yaitu individu dengan status tidak obesitas, baik dilihat dari nilai LP, RLPTB, dan indeks massa tubuh (IMT). Analisis Receiver Operating Characteristic dan Multiple Logistic Regression digunakan dalam analisis data. Hasil penelitian menunjukkan bahwa titik potong RLPTB adalah 0,55 untuk pria dan juga untuk wanita. Kejadian obesitas sentral berdasarkan LP sebesar 18,5% dan berdasarkan RLPTB sebesar 22,3%. Proporsi konsentrasi hs-CRP berisiko setelah 7 tahun adalah 36,5%. Ada perubahan bermakna antara perubahan LP dan perubahan RLPTB dengan perubahan konsentrasi hs-CRP. Indeks RLPTB lebih kuat dalam memprediksi konsentrasi hs-CRP berisiko dibandingkan dengan indeks LP. Mempertahankan kondisi tubuh tidak obesitas sentral pada pralansia dan lansia dapat mencegah dari risiko terjadinya peradangan
Population aging presents major challenges for public health in the world of often being accompanied by a decrease in bodily functions that have an impact on the risk of disease. The aging process is characterized by an increase in the concentration of chronic inflammatory parameters, high sensitivity C-reactive protein (hs-CRP). The age-related increase of inflammatory markers may also account for obesity. This study aimed to assess the relationship of the change of waist circumference (WC) and waist-to-height ratio (WHtR) to the concentration of hs-CRP in the pre-elderly and the elderly in Indonesia, followed through 7 years. A prospective cohort study was conducted using a set of public data of the Indonesian Family Life Survey (IFLS) between 2007 to 2014. A total of 345 subjects of pre-elderly, defined as those aged between 53 to 59 years old, and elderly, aged between 60 to 66 years old, were traced at the baseline of not being obesity based on the value of WC, WHtR, and body mass index (BMI). Receiver-operating characteristic curve and multiple logistic regression analysis were employed for the analysis of data. The WHtR cut-off was 0.55 for both males and females. Central obesity was 18.5% using WC and was 22.3% using WHtR. The proportion of concentration of hs-CRP with risk over 7 years was 36.5%. The associations between central obesity indices (WC and WHtR) and the concentration of hs-CRP were observed. WHtR was found to be stronger predictor of the concentration of hs-CRP than WC. This indicated that managing central obesity among pre-elderly and elderly can help reduce the risk of inflammatory mechanism
D-419
Depok : FKM-UI, 2020
S3 - Disertasi Pusat Informasi Kesehatan Masyarakat
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