Abstrak: Several studies have found an association between sleep duration and morbidity and mortality, but no previous studies have examined the association between sleep disturbances and semen quality. We conducted a cross-sectional study among 953 young Danish men from the general population who were recruited in Copenhagen at the time of determination of fitness for military service between January 2008 and June 2011. All of the men delivered a semen sample, had a blood sample drawn, underwent a physical examination, and answered a questionnaire including information about sleep disturbances. Sleep disturbances were assessed on the basis of a modified 4-item version of the Karolinska Sleep Questionnaire, which includes questions on sleep patterns during the past 4 weeks. Sleep disturbances showed an inverse U-shaped association with sperm concentration, total sperm count, percent motile and percent morphologically normal spermatozoa, and testis size. Men with a high level of sleep disturbance (score >50) had a 29% (95% confidence interval: 2, 48) lower adjusted sperm concentration and 1.6 (95% confidence interval: 0.3, 3.0) percentage points' fewer morphologically normal spermatozoa than men with a sleep score of 11-20. This appears to be the first study to find associations between sleep disturbances and semen quality. In future studies, investigators should attempt to elucidate mechanistic explanations and prospectively assess whether semen quality improves after interventions restoring a normal sleeping pattern.

Abstrak: In a cross-sectional study among 953 young Danish men (2008-2011), Jensen et al. reported that sleep disturbances showed inverse U-shaped associations with semen parameters and testis size (Am J Epidemiol. 2013;177(10):1027-1037). Sleep disturbances were associated with several factors likely to affect semen parameters (such as history of sexually transmitted infections) that cannot all be efficiently controlled for, leaving room for residual confounding. Future studies could adopt a longitudinal design and rely on objective personal measures of sleep quality and duration using accelerometers. Intervention studies would also be helpful to identify whether sleep disturbances (or improvement of sleep quality) can lead to short-term variations in semen parameters. This study adds another suspect to the list of factors possibly influencing male fecundity potential, which also includes overweight, exposure to tobacco smoke (in adulthood and in utero), exposure to specific persistent (lead, organic pollutants) and nonpersistent (some phthalates, bisphenol A) environmental pollutants, and exposure to atmospheric pollutants. Even if each of these factors has a weak impact at the individual level, the large number of factors and the relatively high prevalence of exposure in the general population make it likely that at the population level, lifestyle and environmental factors put a high burden on male fecundity potential.