Ditemukan 2 dokumen yang sesuai dengan query :: Simpan CSV
Sonya Audrelianti Rizal; Pembimbing: Tri Yunis Miko Wahyono; Penguji: Putri Bungsu, Haridana Indah Setiawati Mahdi
Abstrak:
Human Immunodeficiency Virus (HIV) merupakan jenis retrovirus yang menginfeksi dan merusak sel imun dalam tubuh penderita. Virus ini menyerang dan bermultiplikasi pada sel limfosit CD4 hingga melemahkan dan menghancurkan sistem imun tersebut. HIV yang tidak tertangani akan menyebabkan AIDS (acquired immunodeficiency syndrome) yang menyebabkan tuberculosis, diabetes melitus, dan kanker. Menurut Kementerian Kesehatan RI pada tahun 2022 terdapat 90.956 kasus HIV dengan 28.501 kasus kematian. Kanker merupakan penyakit yang umum terjadi pada pasien HIV dimana pasien HIV 50-200 kali lebih tinggi dibandingkan individu yang sehat sehingga muncul kepentingan untuk menekan angka terjadinya kanker melalui beberapa upaya seperti pengadaan layanan konseling HIV, melakukan pengobatan ART dan skrining infeksi oportunistik. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berasosiasi dengan kejadian kanker pada ODHIV menggunakan data rekam medis Rumah Sakit Kanker Dharmais. Penelitian ini dilakukan dengan desain studi cross sectional. Analisis data dilakukan secara univariat dan bivariat menggunakan chi-square dan menampilkan nilai prevalence ratio (95% CI). Berdasarkan analisis, terdapat hubungan yang signifikan antara total CD4, jenis kelamin, dan infeksi oportunistik di Rumah Sakit Kanker Dharmais OR total CD4 <200 3,843 (95% CI 1,741-8,484), OR total CD4 200-499 0,595 (95% CI 0,348-1,007), OR ODHIV perempuan sebesar 0,447 (95% CI 0,271-0,738) dan OR ODHIV dengan infeksi oportunistik 0,327 (95% CI 0,248-0,431).
Human Immunodeficiency Virus (HIV) is a type of retrovirus that infects and damages immune cells in the body. This virus targets and multiplies within CD4 lymphocyte cells, weakening and eventually destroying the immune system. Untreated HIV leads to acquired immunodeficiency syndrome (AIDS), which is associated with opportunistic infections such as tuberculosis, diabetes mellitus, and cancer. According to the Indonesian Ministry of Health, in 2022 there were 90,956 HIV cases with 28,501 deaths reported. Cancer is a common disease among HIV patients, who have a 50-200 times higher risk compared to healthy individuals, highlighting the need to reduce cancer incidence through efforts such as providing HIV counselling services, administering ART treatment, and screening for opportunistic infections. This study aims to identify factors associated with cancer incidence in PLHIV using medical record data from Dharmais Cancer Hospital. The research employs a cross-sectional study design. Data analysis was conducted using univariate and bivariate methods, with chi-square tests and prevalence ratios (95% CI) presented. Based on the analysis, significant associations were found between total CD4 count, gender, and opportunistic infections. At Dharmais Cancer Hospital, the relative risk (OR) for total CD4 <200 was 3.843 (95% CI 1.741-8.484), for total CD4 200-499 was 0.595 (95% CI 0.348-1.007), for female PLHIV was 0.447 (95% CI 0.271-0.738), and for PLHIV with opportunistic infections was 0.327 (95% CI 0.248-0.431).
Read More
Human Immunodeficiency Virus (HIV) is a type of retrovirus that infects and damages immune cells in the body. This virus targets and multiplies within CD4 lymphocyte cells, weakening and eventually destroying the immune system. Untreated HIV leads to acquired immunodeficiency syndrome (AIDS), which is associated with opportunistic infections such as tuberculosis, diabetes mellitus, and cancer. According to the Indonesian Ministry of Health, in 2022 there were 90,956 HIV cases with 28,501 deaths reported. Cancer is a common disease among HIV patients, who have a 50-200 times higher risk compared to healthy individuals, highlighting the need to reduce cancer incidence through efforts such as providing HIV counselling services, administering ART treatment, and screening for opportunistic infections. This study aims to identify factors associated with cancer incidence in PLHIV using medical record data from Dharmais Cancer Hospital. The research employs a cross-sectional study design. Data analysis was conducted using univariate and bivariate methods, with chi-square tests and prevalence ratios (95% CI) presented. Based on the analysis, significant associations were found between total CD4 count, gender, and opportunistic infections. At Dharmais Cancer Hospital, the relative risk (OR) for total CD4 <200 was 3.843 (95% CI 1.741-8.484), for total CD4 200-499 was 0.595 (95% CI 0.348-1.007), for female PLHIV was 0.447 (95% CI 0.271-0.738), and for PLHIV with opportunistic infections was 0.327 (95% CI 0.248-0.431).
S-11865
Depok : FKM UI, 2025
S1 - Skripsi Pusat Informasi Kesehatan Masyarakat
☉
M.Fadillah Mulya ; Pembimbing: Tri Yunis Miko Wahyono; Penguji: Renti Mahkota, Hidayat Nuh Ghazali Djadjuli, Della Ariyani
Abstrak:
Read More
Penelitian ini bertujuan untuk menganalisis karakteristik pasien HIV/AIDS yang menjalani terapi antiretroviral (ARV), menggambarkan ketahanan hidup berdasarkan analisis survival, serta mengidentifikasi faktor-faktor yang berhubungan dengan risiko kematian dan menentukan faktor yang paling dominan di RSUD Provinsi Banten periode 2021–2024. Dari 262 pasien yang diikutsertakan, sebanyak 87 pasien (33,2%) meninggal selama masa follow-up. Analisis Kaplan–Meier menunjukkan ketahanan hidup yang lebih rendah pada pasien dengan CD4 <200 sel/mm³, infeksi oportunistik, dan stadium penyakit lanjut. Pada analisis multivariat menggunakan regresi Cox proportional hazards, CD4 <200 sel/mm³ (aHR = 17,02; IK95%: 3,17–91,27) dan infeksi oportunistik (aHR = 2,11; IK95%: 1,06–4,18) berhubungan secara independen dengan peningkatan risiko kematian. Disimpulkan bahwa CD4 rendah merupakan faktor paling dominan, sehingga deteksi dini, inisiasi ARV tepat waktu, serta pencegahan dan penatalaksanaan infeksi oportunistik perlu menjadi prioritas dalam upaya menurunkan mortalitas HIV di Provinsi Banten.
This study aimed to identify factors associated with mortality among people living with HIV/AIDS (PLWHA) receiving antiretroviral therapy (ART) at a referral hospital in Banten Province during 2021–2024. A retrospective cohort study was conducted using medical records and the SIHA 2.1 database, including 262 patients. Survival analysis was performed using Kaplan–Meier methods and Log-Rank tests, followed by multivariable Cox proportional hazards regression. During follow-up, 87 patients (33.2%) died. Kaplan–Meier curves demonstrated significantly lower survival among patients with CD4 counts <200 cells/mm³ and opportunistic infections. In the adjusted model, CD4 <200 cells/mm³ (aHR = 17.02; 95% CI: 3.17–91.27) and opportunistic infections (aHR = 2.11; 95% CI: 1.06–4.18) were independently associated with increased mortality risk. Low CD4 count was the strongest predictor of death. These findings emphasize the need for early HIV diagnosis, timely ART initiation, and optimal management of opportunistic infections to reduce HIV-related mortality.
T-7490
Depok : FKM-UI, 2026
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
☉