Abstrak: Celiac disease (CD) is associated with increased mortality rate and adverse pregnancy outcome, but little is known about offspring mortality rate. In this nationwide retrospective cohort study, we identified persons whose biopsy-verified CD was diagnosed in Sweden in 1969-2008. We compared mortality rates in children born to mothers with and without CD (n = 16,121 vs. n = 61,782) and children born to fathers with and without CD (n = 9,289 vs. n = 32,984). Median age of offspring at end of follow-up was 28.7 (range, 16.7-39.7) years. We also examined mortality rates in children born to mothers with undiagnosed CD (later CD diagnosis; n = 12,919) and diagnosed CD (n = 3,202) to determine if intrauterine exposures associated with CD could affect offspring mortality rate. We estimated hazard ratios for death by using Cox regression. Death rates were independent of maternal CD (60 deaths per 100,000 person-years in children of mothers with CD, vs. 54 in controls) and paternal CD (53 deaths per 100,000 person-years in children of fathers with CD, vs. 53 in controls). Corresponding adjusted hazard ratios were 1.09 (95% confidence interval: 0.95, 1.26) for maternal CD and 1.02 (95% confidence interval: 0.85, 1.23) for paternal CD. Death rates were similar in children born to mothers with undiagnosed CD and in children whose mothers had diagnosed CD during pregnancy. Parental CD does not seem to influence mortality rate in offspring, which suggests that neither genetic influences of CD nor intrauterine conditions have adverse effects on offspring mortality rate.

Abstrak: Tesis ini membahas tentang efektivitas sistem pencatatan kematian dan penyebab kematian di Provinsi DKI Jakarta dalam menghasilkan statistik vital kematian dan penyebab kematian yang akurat, menyeluruh dan sewaktu. Metode yang digunakan adalah deskriptif analitik dengan pendekatan kualitatif dengan melakukan wawancara mendalam dan studi data sekunder. Hasil penelitian ini menunjukkan bahwa Provinsi DKI Jakarta memiliki dua sistem yang terpisah dan belum disinkronisasi antara pencatatan kematian dengan pencatatan penyebab kematian. Hal ini menyebabkan statistik vital yang dihasilkan oleh kedua sistem tersebut berbeda satu dengan yang lain sehingga belum efektif menghasilkan statistik vital kematian dan penyebab kematian yang akurat, menyeluruh dan sewaktu. Kata kunci: efektivitas, pencatatan kematian, pencatatan penyebab kematian, statistik vital This study discusses the effectiveness of death and cause of death registration system in DKI Jakarta Province to produce accurate, thorough and timely death and cause of death vital statistics. A qualitative research has been conducted with in-depth interview and secondary data studies as methods for data collection. The results showed that DKI Jakarta Province has two separate systems between the death and the cause of death registration and not yet synchronized. The vital statistics generated differ from one another, so that it has not been effective in generating accurate, thorough and timely death and cause of death vital statistics. Keywords: effectiveness, death registration, causes of death registration, vital statistic