Abstrak: Abstrak
Menopause merupakan menstruasi yang berhenti secara permanen yangamong 45 _ 60 years old. Sample was 407 menopausal women taken

Abstrak: Tumor secara umum berarti benjolan yang disebabkan pertumbuhan sel abnormal dalam tubuh. Tumor payudara dapat menjadi faktor risiko kanker payudara yang merupakan kanker yang tersering terjadi pada perempuan. Kejadian tumor payudara meningkat setiap tahunnya di Indonesia. Saat ini, tumor payudara tidak hanya menyerang pada usia lanjut, namun juga usia muda. Beberapa penelitian menunjukkan faktor reproduksi berhubungan dengan tumor payudara. Maka dari itu, penelitian ini bertujuan untuk mengetahui hubungan riwayat reproduksi dengan kejadian tumor payudara pada perempuan usia muda di Indonesia tahun 2016. Penelitian ini menggunakan desain studi cross setional menggunakan data sekunder dari Riset PTM 2016. Sampel penelitian berjumlah 14.891 responden usia di bawah 40 tahun dalam Riset PTM yang memenuhi kriteria inklusi dan eksklusi. Variabel yang diteliti dalam penelitian ini yaitu variabel independen yang terdiri dari usia menarche, usia pertama melahirkan, status kawin, riwayat menyusui, riwayat penggunaan kontrasepsi hormonal; dan variabel dependen yaitu kejadian tumor payudara. Hasil penelitian menunjukkan adanya hubungan usia menarche (OR=1,294), status perkawinan (OR=1,568), usia pertama melahirkan (OR=1,570), riwayat menyusui (OR=1,422), dan riwayat kontrasepsi (OR=0,721) dengan kejadian tumor payudara pada perempuan usia muda di Indonesia. Hal tersebut dapat dipengaruhi karena peranan hormon reproduksi estrogen dan progesteron. Perlu dilakuakn pencegahan pada riwayar reproduksi untuk mencegah tumor payudara.
Kata kunci: tumor payudara, riwayat reproduksi, hormonal, estrogen, cross-sectional

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Neoplasm or tumor generally means an abnormal cell growth in the body. Breast tumors can be a risk factor for breast cancer which is the most common cancer in women. The incindence increases every year in Indonesia. At present, breast tumors do not only attack the elderly, but also at young age. Some studies show factors associated with breast tumors. Therefore, this study aimed to study the association of the reproductive history with tumor incidence in young women in Indonesia in 2016. This study used a crosssectional study design using secondary data from the Riset PTM 2016 (Noncommunicable Disease Research 2016). The sample was 14,891 respondents aged under 40 years who meet the inclusion and exclusion criteria. The variables used in this study were independent variables consisting of age of menarche, age of first birth, marital status, breasfeeding history, the use of hormonal contraception; and the dependent variable is the incidence of breast tumors. The results showed an association between menarche age (OR = 1,294), marital status (OR = 1,568), age of first birth (OR = 1,570), breasteeding history (OR = 1,422), and the use of hormonal contraception (OR = 0,721) with breast tumors in young women in Indonesia This can be caused by the role of estrogen and progesterone reproductive hormones that result excessive proliferation.
Keywords: breast tumors, reproductive history, hormones, estrogen, cross-sectional

Abstrak: The aim of this study was to investigate whether night work is related to breast cancer receptor status. The effect of night work on the risk of estrogen receptor- and progesterone receptor-defined breast cancers was evaluated in 513 nurses diagnosed with breast cancer between 1996 and 2007 and in 757 frequency-matched controls, all of whom were selected from a cohort of Norwegian nurses. Odds ratios for the exposure "duration of work with a minimum of 6 consecutive night shifts" were compared for tumor subgroups with respect to the common control group through the use of polytomous logistic regression. Statistically significant associations were observed between breast cancer and work durations of ≥ 5 years with ≥ 6 consecutive night shifts, with the highest risk observed for progesterone receptor-positive tumors (odds ratio = 2.4, 95% confidence interval: 1.3, 4.3; P-trend = 0.01). When the exposure variable was dichotomized (ever/never worked ≥ 6 consecutive night shifts), a borderline statistically significant heterogeneity (P = 0.05) was seen between progesterone receptor-positive and progesterone receptor-negative tumors in postmenopausal women. The association observed between consecutive night shifts and progesterone receptor-positive cancers suggests that progesterone could play an important role in the detrimental effects of night work.