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A.M. Brodie, R.M. Lucas, S.L. Harrison, I.A.F. van der Mei, B. Armstrong, A. Kricker, R.S. Mason, A.J. McMichael, M. Nowak, D.C. Whiteman, M.G. Kimlin
Abstrak: Observational studies suggest that people with a high serum 25-hydroxyvitamin D (25(OH)D) concentration may have reduced risk of chronic diseases such as osteoporosis, multiple sclerosis, type 1 diabetes, cardiovascular disease, and some cancers. The AusD Study (A Quantitative Assessment of Solar UV Exposure for Vitamin D Synthesis in Australian Adults) was conducted to clarify the relationships between ultraviolet (UV) radiation exposure, dietary intake of vitamin D, and serum 25(OH)D concentration among Australian adults residing in Townsville (19.3°S), Brisbane (27.5°S), Canberra (35.3°S), and Hobart (42.8°S). Participants aged 18-75 years were recruited from the Australian Electoral Roll between 2009 and 2010. Measurements were made of height, weight, waist:hip ratio, skin, hair, and eye color, blood pressure, and grip strength. Participants completed a questionnaire on sun exposure and vitamin D intake, together with 10 days of personal UV dosimetry and an associated sun-exposure and physical-activity diary that was temporally linked to a blood test for measurement of 25(OH)D concentration. Ambient solar UV radiation was also monitored at all study sites. We collected comprehensive, high-quality data from 1,002 participants (459 males, 543 females) assessed simultaneously across a range of latitudes and through all seasons. Here we describe the scientific and methodological issues considered in designing the AusD Study.
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AJE Vol.177, No.9
Oxford : Oxford University Press, 2013
Indeks Artikel Jurnal-Majalah   Pusat Informasi Kesehatan Masyarakat
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Andreas Soejitno, R.A. Tuty Kuswardhani
CDK Vol.36, No.2 (2009)
Jakarta : Kalbe Farma, 2009
Indeks Artikel Jurnal-Majalah   Pusat Informasi Kesehatan Masyarakat
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Achmad Zaki; Promotor: Sudarto Rono admojo; Kopromotor: Ratna Djuwita, Nurhayati A Prihartono; Penguji: Sabarinah Prasetyo, Andri MT Lubis, Rimbawan, Agus Hadi Rahiman
Abstrak: ABSTRAK
 
 
Saat ini terdapat perbaikan Angka Harapan Hidup (AHH) penduduk Indonesia dan penambahan populasi penduduk lanjut usia. Pada tahun 2017, AHH mencapai 71,06 tahun, dan jumlah lansia 23,4 juta orang (8,97% dari seluruh penduduk Indonesia). Hal ini berisiko meningkatkan kejadian penyakit degeneratif. Osteoartritis (OA) adalah penyakit yang sering dikaitkan dengan kondisi degeneratif dan mengakibatkan ketidakaktifan fisik. Pada Riskesdas 2013, penyakit Artritis berada di urutan kedua penyakit terbanyak diderita lansia dengan prevalensi 45% (55-64 tahun), 51,9% (65-74 tahun) dan 54,8% (usia >75 tahun). Pengobatan simtomatik dengan OAINS yang berkepanjangan dapat mengakibatkan efek samping yang fatal. Terdapat berbagai faktor risiko berkembangnya OA lutut, di antaranya konsentrasi serum Vitamin D (25(OH)D. Proporsi perempuan lansia dengan defisiensi 25(OH)D pada penelitian di Jakarta dan Bekasi mencapai 35,1%. Terdapat hubungan antara kadar Vitamin D (25(OH)D) yang rendah dengan nyeri lutut dan perubahan kartilago sendi lutut pada OA. Serum Cartilage Oligomeric Matrix Protein (COMP) merupakan produk degradasi penting dari kartilago sendi dan dapat menjadi marker diagnosis untuk OA lutut. Penelitian ini bertujuan mengetahui pengaruh pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu terhadap derajat nyeri berdasarkan indikator WOMAC, dan kondisi obyektif kartilago sendi dengan perubahan marker serum COMP pada penderita OA lutut lansia. Disain penelitian uji klinis teracak, tersamar ganda, dan terkontrol plasebo. Subyek dengan OA lutut simtomatis direkruit secara consecutive sampling dan dilakukan anamnesis, diperiksa kondisi fisik, radiologi lutut, kadar serum Vitamin D (25(OH)D), serum Calcium dan marker COMP. Subyek dialokasikan secara acak (random allocation) pada kelompok perlakuan yang diberikan suplemen Vitamin D (Alphacalcidol) atau kelompok kontrol yang diberikan plasebo. Populasi sumber xviii Universitas Indonesia pada penelitian ini ialah pasien OA lutut lanjut usia yang berobat ke KPKM FKIK UIN Jakarta. Dari hasil pemeriksaan konsentrasi serum Vitamin D 25(OH)D sebelum dilakukan intervensi, 53,4% responden mengalami insufisiensi dan 12,3% responden mengalami defisiensi Vitamin D. Pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu, mempengaruhi penurunan derajat nyeri berdasarkan indikator WOMAC pada penderita OA lutut lansia yang bermakna secara statistik dengan perbedaan perubahan skor pra dan pascaintervensi pada kelompok intervensi dibanding kontrol sebesar 2,174 (p=0,00). Pemberian suplemen Vitamin D (Alphacalcidol) selama 12 minggu, mempengaruhi penurunan konsentrasi serum COMP pada penderita OA lutut lansia, dengan perbedaan perubahan skor pra dan pascaintervensi pada kelompok intervensi dibandingkan kelompok kontrol sebesar 38,15 ng/ml namun tidak bermakna secara statistik (p=0,39)
 
ABSTRACT
 
 
At present there are improvements in the Life Expectancy (AHH) of the Indonesian population and the addition of the elderly population. In 2017, AHH reached 71.06 yo and the number of elderly people reached 23.4 million people (8.97% of the total population of Indonesia). This has the potential to increase degenerative diseases. Osteoarthritis (OA) is a disease that is often associated with degenerative conditions and physical inactivity. Riskesdas in 2013 stated that Arthritis was the second most common disease suffered by the elderly with a prevalence of 45% (55-64 yo), 51.9% (65-74 yo) and 54.8% (>75 yo). Symptomatic treatment with prolonged NSAIDs can cause fatal side effects. There are various risk factors for developing knee OA, including serum Vitamin D (25(OH)D) concentrations. The proportion of elderly women with 25(OH)D deficiency in studies in Jakarta and Bekasi reaches 35.1%. It has been found an association between low Vitamin D levels (25(OH)D) with knee pain in OA and changes in the knee joint cartilage. Cartilage Oligomeric Matrix Protein (COMP) is an important degradation product of joint cartilage and can be act as a diagnostic marker of knee OA. This study aims to determine the effect of Vitamin D supplementation (Alphacalcidol) for 12 weeks on the degree of pain based on WOMAC indicators, and the objective conditions of joint cartilage with changes in COMP serum markers in patients with knee OA in the elderly. The research design is a randomized, double-blind, and placebo-controlled clinical trials. Subjects with symptomatic knee OA will be recruited by consecutive sampling and continued with history taking, physical conditions examinatons, knee radiology, and blood test for serum vitamin D (25(OH)D), serum calcium and marker COMP. Subjects were then randomly allocated to the treatment group given Vitamin D supplements (Alphacalcidol) or the control group given a placebo. The source population in this study was elderly with knee OA patients xx Universitas Indonesia who went to Primary Health Care Clinic (KPKM) of FKIK UIN Jakarta. We found that before intervention was done, 53.4% of respondents had Vitamin D insufficiency and 12.3% of respondents had Vitamin D deficiency. The administration of Vitamin D supplements (Alphacalcidol) for 12 weeks, influenced the decrease in the degree of pain based on the WOMAC indicator in knee OA of elderly patients significantly, with differences in changes in pre and post intervention scores of 2.174 compare with control (p=0.00). The administration of Vitamin D supplements (Alphacalcidol) for 12 weeks, affected the decrease in the serum concentration of COMP in knee OA of elderly patients, with differences in changes in pre and post intervention scores in the intervention group compared to the control group of 38.15 ng/ml but not statistically significant (p=0.39).
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D-401
Depok : FKM-UI, 2019
S3 - Disertasi   Pusat Informasi Kesehatan Masyarakat
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Shin-Wen Lin ... [et al.]
AJE Vol.178, No.4
Oxford : Oxford University Press, 2013
Indeks Artikel Jurnal-Majalah   Pusat Informasi Kesehatan Masyarakat
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Anne-Louise Ponsonby ... [et al.]
AJE Vol.168, No.4
Oxford : Oxford University Press, 2008
Indeks Artikel Jurnal-Majalah   Pusat Informasi Kesehatan Masyarakat
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Elly, Nur/ Promotor: Djuwita, Ratna/ Kopromotor: Purwantyastuti; Rimbawan/ Penguji: Laksminingsih, Endang; Rini Sekartini, Besral, Mira Dewi, Noer Laily
D-396
Depok : FKM-UI, 2019
S3 - Disertasi   Pusat Informasi Kesehatan Masyarakat
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Erni Yusnita Lalusu; Promotor: Ratna Djuwita Hatma; Kopromotor: Mondastri Korib Sudaryo, Dwiana Ocviyanti; Penguji: Pradana Soewondo, Endang L. Achadi, Besral; Rimbawan, Anang S. Otoluwa
Abstrak:
Penelitian bertujuan untuk mengetahui perbedaan kadar glukosa darah selama kehamilan diantara ibu hamil yang diberikan suplemen MGM sejak periode prakonsepsi (Grup 1.), yang diberikan suplemen MGM sejak awal kehamilan (Grup 2.), dan yang diberikan Fe+Folat sejak awal kehamilan (Grup 3.) setelah mengendalikan berbagai kovariat. Metode: Ini adalah penelitian quasi eksperimen dengan non-randomize community trial with pre and post-test control group design, yang melibatkan 25 orang pada grup 1, 41 orang pada grup 2, dan 37 orang ibu hamil pada grup 3. Kadar glukosa darah diperiksa pada baseline studi, minggu ke-12, 24, dan 28 kehamilan. Pengukuran dan pengambilan data menggunakan instrument terstandar. Pengukuran dan analisis glukosa darah dilakukan di laboratorium dengan metode terstandar. Analisis multivariat menggunakan Regresi Linear Generalized Estimated Equation (GEE). Hasil penelitian: Pada minggu ke-24 kehamilan antara grup 1 dan grup 3 menunjukkan perbedaan rerata kadar glukosa darah yang signifikan (p<0.001). Demikian pula antara grup 2 dan grup 3 (p<0.001). Grup 1 dan 2 lebih rendah (87 (53-111) mg/dl dan 86 (65-110) mg/dl) dibandingkan dengan grup 3 yaitu 115 (68-204) mg/dl. Pada minggu ke-28 juga menunjukkan perbedaan (p<0.001). Rerata kadar glukosa darah grup 1 = 91(53-141) mg/dl, grup 2 = 93 (62-146) dan grup 3 = 137 (74-244) mg/dl. Analisis multivariat menunjukkan pada minggu ke-24 rerata GDS ibu hamil pada grup 3 lebih tinggi 26 mg/dl dari grup 1 (p<0.001). Demikian pula pada minggu ke-28, rerata glukosa darah grup 3 lebih tinggi 48mg/dl dibandingkan grup 1 (p<0.001). Sedangkan antara grup 2 dan grup 1 tidak menunjukkan perbedaan yang signifikan baik pada minggu ke-24 (p=0.891) maupun pada minggu ke-28 (p=0.762). Pemberian suplemen MGM sejak periode prakonsepsi maupun sejak awal kehamilan menunjukkan kadar glukosa darah yang lebih rendah dibandingkan pada pemberian Fe+folat. Namun demikian, antara pemberian MGM sejak prakonsepsi dengan pemberian sejak awal kehamilan tidak menunjukkan perbedaan yang signifikan dalam kadar glukosa darah. Dibutuhkan penelitian lanjutan untuk memperkuat bukti temuan ini dengan menggunakan parameter yang lebih spesifik dan menerapkan prosedur randomisasi.
This study was conducted to determine the difference in Blood Glucose Level (BGL) during pregnancy between pregnant women who were given MMS since the preconception period (Group 1.), given MMS since early pregnancy (Group 2.), and those who were given iron-folic acid (IFA). early in pregnancy (Group 3.) after controlling for various covariates. This is a quasi-experimental study with a non-randomized community trial with a pre and post-test control group design, involving 25 people in group 1, 41 people in group 2, and 37 people in group 3. BGLs The examination is carried out at the 12th, 24th, and 28th weeks of pregnancy. Measurement and data collection using standardized instruments. BGL measurements and analyzes were performed in a standardized laboratory. Multivariate analysis using Generalized Estimated Equation Linear Regression (GEE). Results: At the 24th week of gestation, group 1 and group 3 showed a significant difference in the mean of BGL (p<0.001). Similarly, between group 2 and group 3 (p<0.001). Groups 1 and 2 were lower (87 (53-111) mg/dl and 86 (65-110) mg/dl) compared to group 3 at 115 (68-204) mg/dl. 28th Week also showed a difference (p<0.001). The mean blood glucose levels in group 1 = 91(53-141) mg/dl, group 2 = 93 (62-146) and group 3 = 137 (74-244) mg/dl. Multivariate analysis showed that at the 24th week the mean BGL of pregnant women in group 3 was 26 mg/dl higher than in group 1 (p<0.001). Similarly, at the 28th week, the mean BGL of group 3 was 48mg/dl higher than group 1 (p<0.001). Meanwhile, there was no significant difference between group 2 and group 1 at week 24 (p=0.891) or at week 28 (p=0.762). The administration of MMS supplements since the preconception period and since the beginning of pregnancy showed lower blood glucose levels than the administration of IFA. However, the administration of MMS since preconception and early pregnancy did not show a significant difference in blood glucose levels. Further research is needed to strengthen the evidence of these findings by using more specific parameters and applying randomization procedures.
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D-469
Depok : FKM-UI, 2022
S3 - Disertasi   Pusat Informasi Kesehatan Masyarakat
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Ika Dewi Subandiyah; Promotor: Nurhayati Adnan; Kopromotor: Ratna Djuwita, Nastiti Kaswandani; Penguji: Besral, Tri Yunis Miko Wahyono, Titis Prawitasari, Siti Nur Anisah, Nininig Mularsih
Abstrak:

Insidens kasus tuberkulosis (TBC) anak di Indonesia diperkirakan mencapai 11,7% dari total kasus TB. Tidak semua individu terpapar TBC akan menjadi sakit, namun kemungkinan reaktivasi lebih tinggi pada anak , terutama pada anak di bawah lima tahun. Kontak serumah lebih berisiko. Nutrisi baik makro maupun mikro mempengaruhi kejadian TBC pada anak. Studi menyatakan Vitamin D dan Seng berperan dalam peningkatan imunitas. Namun penelitian tentang pemberian suplementasi vitamin D dan Seng serta upaya perbaikan nutrisi dalam pencegahan infeksi TBC pada balita belum dilakukan. Penelitian ini bertujuan untuk mengetahui efek pemberian suplementasi dan konseling diet dalam pencegahan infeksi TBC pada balita kontakserumah TBC paru terkonfirmasi bakteriologis di DKI Jakarta. Kami melakukan penelitian quasi eksperimen pada balita kontak serumah TBC paru bakteriologis di 25 kecamatan di DKI Jakarta. Kelompok intervensi diberikan vitamin D 400-600 IU/hari dan Seng 10-20mg/hari tergantung usia selama 3 bulan serta konseling diet pada orang tua. Balita yang masuk dalam sampel adalah balita yang tidak terinfeksi dan atau sakit TBC, tidak gizi buruk, HIV negative dan tidak menderita penyakit kronis lain. Setiap bulan  dilakukan recall diet 24 jam untuk mengukur nutrisi dan status gizi. Setelah 3 bulan akan dihitung balita yang terinfeksi dan tidak dengan menggunakan tes tuberculin. Analisa multivariat dilakukan dengan GEE. Berdasarkan hasil penelitian, insidenss kumulatif infeksi TBC pada kelompok intervensi 5% sedangkan pada kelompok kontrol 23%. Pemberian intervensi meningkatkan konsumsi vitamin D pada balita yakni dari 3 mcg menjadi 14,9 mcg dan Seng 3.8 mg menjadi 18.2 mg. Pada balita terinfeksi, konsumsi  vitamin D dan Seng lebih rendah. Besarnya risiko kejadian infeksi TBC dengan pemberian intervensi adalah 0.22 kali ( 95% CI 0.08-0.57 p. value 0.002). Pemberian suplementasi vitamin D dan Seng serta konseling diet  menurunkan kejadian infeksi TBC pada balita kontak serumah hingga 78%. Kata Kunci : Infeksi TBC pada balita kontak serumah, suplementasi vitamin D dan Seng, quasi eksperimen, tes tuberculin

 

The incidence of childhood tuberculosis (TB) in Indonesia is estimated to be 11.7% of total TB cases. Not all individuals exposed to TB will become ill, but the likelihood of reactivation is higher in children, especially children under five years old. Household contacts are more at risk. Both macro and mikro nutriens influence the incidence of TB in children. Studies suggest that vitamin D and zinc play a role in boosting immunity. However, research on vitamin D and zinc supplementation and nutritional improvement efforts in preventing tuberculosis infection in children under five years of age has not been conducted. This study aims to determine the effect of supplementation and dietary counseling in preventing TB infection in young children with bacteriologically confirmed pulmonary TB in DKI Jakarta. We conducted a quasi-experimental study among infants with bacteriologically confirmed pulmonary TB home contacts in 25 subdistricts in DKI Jakarta. The intervention group received vitamin D 400-600 IU/day and Zinc 10-20mg/day depending on age for 3 months, as well as nutritional counseling for parents. Included in the sample were infants who were not infected and/or sick with TB, not malnourished, HIV negative, and not suffering from any other chronic diseases. A 24-hour dietary recall to measure diet and nutritional status was conducted every month. After 3 months, infected and uninfected children were counted using the tuberculin test. Multivariate analysis was performed using GEE. Based on the results of the study, the cumulative incidence of TB infection was 5% in the intervention group and 23% in the control group. The intervention increased vitamin D consumption in toddlers from 3 mcg to 14.9 mcg and zinc from 3.8 mg to 18.2 mg. Vitamin D and zinc intake was lower among infected infants. The risk of TB infection with the intervention was 0.22 times (95% CI 0.08-0.57 p. value 0.002). Provision of vitamin D and zinc supplementation and dietary advice reduced the risk of TB infection. Keywords: Infection of TB in Household contact children under five years age, Tuberculin Test, Suplementation of vitamin D and zinc, Quasi experimental studies

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D-550
Depok : FKM UI, 2025
S3 - Disertasi   Pusat Informasi Kesehatan Masyarakat
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