Kata KunciBayesian inference; Markov chain Monte Carlo; data augmentation; infection control; methicillin-resistant Staphylococcus aureus; patient isolation
650 Subyek
700 Pengarang TambahanWorby, Colin J.; Jeyaratnam, Dakshika; Robotham, Julie V.; Kypraios, Theodore; O'Neill, Philip D.; Angelis, Daniela De; French, Gary; Cooper, Ben S.
850 Badan PemilikPusinfokesmas FKM UI
852 LokasiLantai 5
500 Catatan Umum
245c PertanggungjawabanColin J. Worby, Dakshika Jeyaratnam, Julie V. Robotham, Theodore Kypraios, Philip D. O'Neill, Daniela De Angelis, Gary French, Ben S. Cooper
245 JudulEstimating the effectiveness of isolation and decolonization measures in reducing transmission of methicillin-resistant staphylococcus aureus in hospital general wards
856 Lokasi File ElektronikDOI: https://doi.org/10.1093/aje/kws380
260c Tahun Terbit2013
Penerbit dan Distribusi
100 Pengarang Utama
022 ISSN
082 No. PanggilAJE Vol.177, No.11
260a Kota TerbitOxford
786 Sumber DataAmerican Journal of Epidemiology
003 Barcode28-23-28631511
abstrakInfection control for hospital pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) often takes the form of a package of interventions, including the use of patient isolation and decolonization treatment. Such interventions, though widely used, have generated controversy because of their significant resource implications and the lack of robust evidence with regard to their effectiveness at reducing transmission. The aim of this study was to estimate the effectiveness of isolation and decolonization measures in reducing MRSA transmission in hospital general wards. Prospectively collected MRSA surveillance data from 10 general wards at Guy's and St. Thomas' hospitals, London, United Kingdom, in 2006-2007 were used, comprising 14,035 patient episodes. Data were analyzed with a Markov chain Monte Carlo algorithm to model transmission dynamics. The combined effect of isolation and decolonization was estimated to reduce transmission by 64% (95% confidence interval: 37, 79). Undetected MRSA-positive patients were estimated to be the source of 75% (95% confidence interval: 67, 86) of total transmission events. Isolation measures combined with decolonization treatment were strongly associated with a reduction in MRSA transmission in hospital general wards. These findings provide support for active methods of MRSA control, but further research is needed to determine the relative importance of isolation and decolonization in preventing transmission.
260b PenerbitOxford University Press
Tanggal160114
786c Volume/No./Tahun/HlmVol.177, No.11 June. 1, 2013: p.1306-1313
041 Kode Bahasaeng
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