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500 mg with Vitamin E 200 mg to Decrease Oxidative Stress and Increase Antioxidant on Technician Crew Military Aircraft. Oxidative stress is pathological condition body that is caused by imbalance between oxidants with antioxidants body, which produces free radicals that can lead cell damage early. Free radical will bind building blocks cell covering of fat, protein and DNA will result damage cell, so cell can not regenerate that affect onset of degenerative diseases. Technicians crew military aircraft as specialized personnel with activity job direct contact with material oxidant, thus high risk of oxidative stress. Vitamin C and vitamin E are antioxidant enzyme exogen outside body which has role inhibiting oxidative stress, so oxidative stress does not occur. The design study experimental studies with intervention randomized double blind controled trial. Sample size 206 people divided into two groups are intervention group with sample size 103 people are given supplements combination vitamin C 500 mg with vitamin E 200 mg and control group with sample size 103 people are given placebo for 40 days without break. Data collected include are characteristics of respondent, pattern and amount of consumption of vitamin C, vitamin E and nutrient food, derived from food frequecy questionnaire (FFQ) and 24-hour recall, examination of oxidative stress by checking levels malondialdehyde (MDA) and examination of antioxidant by checking levels glutathione (GSH) in blood serum in pre and post intervention. The results showed decrease oxidative stress in group intervention who are received suplement combination vitamin C 500 mg with vitamin E 200 mg compared with control group who are received placebo, are significant with p value 0.04 with effects size -0.089 nmol/mL, confidence interval 95 % (-0.17875 - 0.00095). No increase antioxidants in group intervention who are received supplement combination vitamin C 500 mg with vitamin E 200 mg compared with control group who are received placebo, are not significant with p value 0.81 with effects size -0.019 ug/mL, 95% confidence interval ( -0.140 - 0.180).
ABSTRACT
Pestisida banyak memberi andil dalam peningkatan kesejahteraan masyarakat. Dalam bidang kesehatan masyarakat pestisida digunakan untuk mengendalikan vektor penyakit menular sehingga dapat menurunkan prevalensi penyakit seperti: malaria, demam berdarah, pes dan sebagainya. Namun dengan sifatnya sebagai racun biosid, efek pestisida tidak saja berlaku bagi hama yang menjadi target sasarannya, tapi juga memberikan dampak negative terhadap mahluk hidup lainnya termasuk manusia.DKI Jakarta sebagai kota jasa memiliki 97 perusahaan yang bergerak dalam jasa pelayanan pest control dengan pekerjanya memiliki resiko keracunan kronik dengan paparan tinggi, ini dapat dilihat dari hasil pemeriksaan cholinesterase darah teknisi yang menunjukan telah terjadinya keracunan, dan pada tahun 2001 angka prevalensinya mencapai 8,2%.Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan atas pelindung diri dengan aktifitas cholinesterase pada teknisi perusahaan pest control di DKI Jakarta pada tahun 2002. Ini merupakan penelitian observasional dengan metoda case control. Responden dalam penelitian ini adalah teknisi pada perusahaan pest control yang memiliki aktifitas cholinesterase tidak normal (2,3) dari hasil pemeriksaan pada tahun 2001 sebagai kasus dan teknisi dengan hasil pemeriksaan aktifitas cholinesterase normal sebagai kontrol pada perusahaan yang sama dengan kasus bekerja dengan perbandingan 1:2 (40 kasus dan 80 kontrol). Analisis data dilakukan dengan uji chi square dan analisis inultivariate logistic regression.Hasil uji analisis logistik diketahui ada hubungan yang signifikan antara penggunaan Alat Pelindung Diri (APD) dengan aktifitas cholinesterase pada teknisi pest control di DKI Jakarta dengan OR 2,995 ( CI 95%: 1,303-6,886) yang berani risiko teknisi dengan aktifitas cholinesterase tidak normal 2,995 kali terjadi pada teknisi yang tidak menggunakan APD lengkap dibanding teknisi dengan cholinesterase normal setelah dikontrol oleh variable lain yaitu perilaku dan makan, minum dan atau merokok selama bekerja.Disimpulkan bahwa penggunaan APD mempunyai hubungan yang signifikan dengan aktifitas cholinesterase pada teknisi pest control, dan untuk melakukan penanggulangan dan pencegahan masalah ini yaitu dengan memberikan perhatian dan penekanan pada penggunaan APD yang tidak lengkap, dan melakukan upaya-upaya yang berkaitan diantaranya peningkatan pengetahuan dan kesadaran pada teknisi dan melakukan pengawasan terhadap penggunaannya serta melakukan pembinaan bagi perusahaan agar menyediakan APD secara lengkap dan sesuai persyaratan.Daftar bacaan : 53 (1983 - 2002)
The Influence of Ppe Using with Cholinesterase Activity on the Technicians of Pest Control Relation Company in DKI Jakarta, 2002Pesticide gives many roles in community welfare. Within public Health field, pesticide is used to control infected diseases so it can reduce disease infection such as: malaria, DBD, pest, and etc. However, with poisoning property as biosid, pesticide effects acts not only to the plant disease as a target but to other creatures as well including human being.Jakarta as a service city has 97 company which running service of pest control field where the employees has the risk against chronic poisoning with high exposure. It can be seen from cholinesterase blood examination of the technicians which showed the poisoning has occurred. And in the year of 2001, the prevalence reaches 8,2%.The research purpose to find out the influences of PPE using (Personnel Protective Equipment) with cholinesterase activity on technicians of pest control Company in DKI Jakarta , 2002. This is Observational research, with case control method. The respondents are the technicians of pest control company having abnormal cholinesterase activity obtained from examination result in 2001 as the case , while examination result of technicians with normal cholinesterase activity as the control in the same company with comparison of occupational case 1:2 (40 cases and 80 controls). Data analysis used chi square test and regression logistic multivariate analysis.Logistic analysis test showed that there is significant relation between using of PPE with the cholinesterase activity on the technicians of pest control company in DKI Jakarta with OR 2,995 (CI 95%; 1,303 -- 6,886), it means that technicians risk against abnormal cholinesterase activity is 2,995 times occurs to the technicians without using completed PPE compared to technicians with normal cholinesterase, and controlled by another variabeles, that is practice and habitual of eat, drink and smoking usually working.It is concluded that PPE using has significant relation to the cholinesterase activity on the technicians of pest control company. Prevention and protection is conducted by giving attention for the inappropriate PPE , and by applying some related efforts such as increasing knowledge, technicians awareness, and monitoring to the PPE, and developing company as well by serving appropriate PPE.References : 53 (1983-2002)
