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Alwiyah Mukaddas; Promotor: Mondastri Korib Sudaryo; Kopromotor: Nurhayati Adnan, Sabarinah; Penguji: Pandu Riono, Tri Yunis Miko Wahyono, Soewarta Kosen; Evy Yunihastuti
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TB (Tuberkulosis) adalah penyebab utama kematian pada orang dengan HIV (ODHIV). Terapi pencegahan TB (TPT) dapat mencegah infeksi TB menjadi penyakit TB aktif. TPT 3HP adalah rejimen yang direkomendasikan karena durasi singkat yang dapat meningkatkan completion therapy. TPT menimbulkan efek samping dan salah satu yang sering terjadi adalah hepatotoksisitas yang dapat diukur dengan pemeriksaan biomarker fungsi hati. Cakupan program TPT pada ODHIV sampai saat ini rendah dan belum diketahui hambatannya. Penelitian ini bertujuan untuk untuk menganalisis tren perubahan biomarker fungsi hati meliputi ALT, ALP, bilirubin total, albumin, faktor R secara longitudinal dan mengevaluasi implementasi program terapi pencegahan tuberkulosis (TPT) 3HP pada orang dengan HIV. Penelitian ini menggunakan pendekatan embedded mix method dengan penelitian kuantitatif berupa studi panel longitudinal pada 189 ODHIV yang terbagi 2 kelompok yaitu penerima TPT 3HP dan non-TPT untuk uji fungsi hati meliputi ALT, ALP, Bilirubin total, albumin dan faktor R dengan analisis statistik model GEE (Generalized Estimating Equation) dengan working correlation auto regressive, distribusi gamma link function log menggunakan SPSS 24. Penelitian kualitatif menggunakan metode evaluasi CIPP dengan indepth-interview kepada 28 informan dengan menggunakan analisis tematik. Penelitian ini dilaksanakan di 5 puskesmas dan 1 rumah sakit di Kabupaten Gowa dan Kota Makassar, Provinsi Sulawesi Selatan. Hasil penelitian menunjukkan bahwa terdapat efek interaksi yang signifikan pada kelompok TPT 3HP dengan waktu terhadap perubahan peningkatan rasio mean ALT 1,16 dan ALP 1,20 pada T1 dan penurunan ALT 0,787 dan ALP 0,765 pada T2. Sedangkan pada dua biomarker lainnya menunjukkan penurunan rasio mean yang konsisten pada T1 dan T2 yaitu bilirubin total 0,848 dan 0,76, albumin 0,924 dan 0,956. Hanya faktor R yang tidak menunjukkan efek interaksi yang signifikan. Terdapat 18 jenis efek samping obat (ESO) dari 47 (49,5%) bulan pertama, kedua (20% ) dan ketiga (7,4%). Completion therapy TPT 3HP 97,9% dengan faktor pendukung kepercayaan terhadap PJ HIV dengan pendekatan interpersonal, terdapat role model, opinion leader subkelompok, intervensi perilaku sederhana (repacking 3HP), efek samping ringan yang self-limiting, dan punya riwayat TB. Kendala utama yang tersisa adalah mutasi SDM, logistik, stigma sosial, variasi pengetahuan nakes, dan ketimpangan akses informasi antar ODHIV. Kesimpulan: Pemberian TPT 3HP dapat merubah tren biomarker ALT, ALP, Bilirubin total dan albumin, dengan kadar yang masih berada dalam rentang nilai normal. Keluhan ESO ringan dan dapat ditoleransi dengan baik oleh ODHIV sehingga completion therapy tinggi.
TB (tuberculosis) is the leading cause of death among people living with HIV (PLHIV). Tuberculosis preventive therapy (TPT) can prevent TB infection from progressing to active TB disease. The 3HP TPT regimen is recommended because its short duration can improve treatment completion rates. TPT causes side effects, and one of the most common is hepatotoxicity, which can be measured through liver function biomarker tests. Coverage of the TPT program among PLHIV remains low, and the barriers to its implementation are not yet known. This study aims to analyze trends in changes in liver function biomarkers—including ALT, ALP, total bilirubin, albumin, and R factor—over time and to evaluate the implementation of the 3HP tuberculosis preventive therapy (TPT) program among people living with HIV. This study employed an embedded mixed-methods approach, with a quantitative component consisting of a longitudinal panel study of 189 people living with HIV divided into two groups: 3HP TPT recipients and non-TPT recipients. Liver function tests—including ALT, ALP, total bilirubin, albumin, and R factor, using statistical analysis with the GEE (Generalized Estimating Equations) model featuring an autoregressive working correlation and a log-gamma link function in SPSS 24. The qualitative study employed the CIPP evaluation method through in-depth interviews with 28 informants, utilizing thematic analysis. This study was conducted at 5 community health centers and 1 hospital in Gowa Regency and Makassar City, South Sulawesi Province. The results of the study showed that there was a significant interaction effect in the TPT 3HP group with time regarding changes in the mean ALT ratio (1.16) and ALP ratio (1.20) at T1, and decreases in the mean ALT ratio (0.787) and ALP ratio (0.765) at T2. Meanwhile, the other two biomarkers showed consistent decreases in mean ratios at T1 and T2, namely total bilirubin at 0.848 and 0.76, and albumin at 0.924 and 0.956. Only the R factor did not show a significant interaction effect. There were 18 types of drug-related adverse events (DRAs) occurring in 47 (49.5%) of the first, second (20%), and third (7.4%) months. The completion rate for 3HP antiretroviral therapy (ART) was 97.9%, supported by factors such as trust in HIV care providers through an interpersonal approach, the presence of role models and subgroup opinion leaders, simple behavioral interventions (3HP repackaging), mild self-limiting side effects, and a history of TB. The main remaining challenges include staff turnover, logistics, social stigma, variations in healthcare workers’ knowledge, and disparities in access to information among people living with HIV (PLHIV). Conclusion: Administration of TPT 3HP can alter trends in the biomarkers ALT, ALP, total bilirubin, and albumin, with levels remaining within the normal range. Adverse drug reactions were mild and well-tolerated by PLHIV, resulting in high treatment completion rates.
D-632
Depok : FKM-UI, 2026
S3 - Disertasi Pusat Informasi Kesehatan Masyarakat
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Feny Ditya Hanifah; Pembimbing: Syahrizal; Penguji: Trisari Anggondowati, Yuniarsih Handayani
T-7025
Depok : FKM UI, 2024
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Arabia Tamrin; Pembimbing: Nurhayati Adnan; Penguji: Syahrizal, Romauli
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HIV merupakan masalah kesehatan masyarakat utama secara global. HIV memerlukan pengobatan seumur hidup sehingga kepatuhan terhadap pengobatan antiretroviral sangat diperlukan oleh ODHIV agar mencapai keberhasilan pengobatan. Tesis ini mengkaji seberapa besar pengaruh tingkat kepatuhan terapi antiretroviral terhadap resiko kegagalan virologis yang dikur dari capaian supresi virus pada orang dengan HIV di Kota Bogor. Penelitian ini merupakan penelitian kuantitatif dengan metode observasional analitik dan desain kasus kontrol melalui pemanfaatan data SIHA versi 1.7 di 11 fasilitas kesehatan. Hasil penelitian didapatkan orang dengan HIV di Kota Bogor dengan kepatuhan terapi rendah memiliki resiko 13,21 kali (95% CI: 6,00-29,06; p: 0,000) menyebabkan virus tidak supresi. Disarankan untuk optimalisasi konseling kepatuhan melalui peran konselor dalam menggali hambatan kepatuhan pada orang dengan HIV di layanan
HIV is a major public health problem globally. requires lifelong treatment so that adherence to antiretroviral treatment is needed by PLHIV to achieve treatment success. This thesis examines how much influence the level of adherence to antiretroviral therapy has on the risk of virological failure as measured by the achievement of virus suppression in people living with HIV in Bogor City. This research is a quantitative study using analytic observational methods and a case-control design using SIHA version 1.7 data in 11 health facilities. The results of the study found that people with HIV in Bogor City with low adherence to therapy had a 13.21 times (95% CI: 6.00-29.06; p: 0.000) risk of causing the virus to not be suppressed. It is suggested to optimize adherence counseling through the counselor's role in exploring adherence barriers in people with HIV in services.
T-6758
Depok : FKM-UI, 2023
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Prisilia Nurul Fajrin K; Pembimbing: Nasrin Kodim; Penguji: Toha Muhaimin, Kurniawan Rahmadi
S-7051
Depok : FKM-UI, 2012
S1 - Skripsi Pusat Informasi Kesehatan Masyarakat
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Nur Wahyu Rahmadiani; Pembimbing: Putri Bungsu; Penguji: Lhuri Dwianti Rahmartani, Siti Zuhroh
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Di Indonesia, kasus kematian terkait Acquired Immune Deficiency Syndrome (AIDS) terus meningkat sebesar lebih dari dua kali lipat dari 11.971 kasus di tahun 2010 menjadi 26.501 di tahun 2022, dan 40% di antaranya disebabkan oleh Tuberkulosis (TBC). AIDS adalah perkembangan dari Human Immunodeficiency Virus (HIV) yang mengakibatkan sistem kekebalan tubuh menurun sehingga Orang Dengan HIV (ODHIV) rentan terkena penyakit atau infeksi oportunistik, termasuk TBC. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berasosiasi dengan adanya status TBC pada ODHIV setelah inisiasi ART dilakukan dengan menggunakan data Sistem Informasi HIV AIDS (SIHA) 2.1. Desain penelitian ini adalah cross sectional dengan sampel penduduk berusia ≥ 15 tahun yang memanfaatkan data Sistem Informasi HIV AIDS tahun 2023 dan menggunakan uji chi-square untuk analisis bivariat dan regresi logistik untuk analisis multivariat. Dari 39.623 ODHIV yang tercatat pada tahun 2023, terdapat 34.662 data yang eligible untuk digunakan dalam penelitian ini. Hasil penelitian ini menunjukkan wilayah dengan prevalensi kasus HIV tertinggi di DKI Jakarta adalah Jakarta Pusat (30,8%) sedangkan wilayah dengan prevalensi HIV-TB tertinggi adalah Jakarta Barat (25,1%). Selanjutnya, ditemukan prevalensi HIV-TB pada populasi ≥ 15 tahun di DKI Jakarta setelah melakukan inisiasi ART adalah 4,4%. Stadium klinis 3 dan 4 (AOR = 9,99; 95% CI = 8,72 – 11,45), Indeks Massa Tubuh (IMT) kurus (AOR = 2,54; 95% CI = 2,22 – 2,91), kelompok usia 25 – 34 tahun (AOR = 2,16; 95% CI = 1,86 – 2,52), tidak mengonsumsi Terapi Pencegahan Tuberkulosis (TPT) (AOR = 17,73; 95% CI = 10,42 – 30,18) adalah faktor risiko yang berpengaruh dalam meningkatkan adanya status TBC pada ODHIV. Selain itu, faktor yang menunjukkan protektif terhadap status TBC pada ODHIV adalah menunda inisiasi Antiretrvorial Therapy (ART) (AOR = 0,10; 95% CI = 0,09 – 0,12) dan kelompok populasi kunci (AOR = 0,44; 95% CI = 0,39 – 0,51). Faktor yang memiliki kontribusi terbesar dalam penelitian ini adalah riwayat konsumsi TPT. Dengan demikian, dibutuhkan peningkatan cakupan TPT untuk dapat mencegah adanya status TBC pada ODHIV dan ODHIV dewasa muda diharapkan dapat meningkatkan pencegahan TBC.
In Indonesia, Acquired Immune Deficiency Syndrome (AIDS) related deaths have more than doubled from 11,971 cases in 2010 to 26,501 in 2022, 40% of which are caused by Tuberculosis (TB). AIDS is a progression of the Human Immunodeficiency Virus (HIV) that results in a decreased immune system so that People Living with HIV (PLHIV) are susceptible to opportunistic diseases or infections, including tuberculosis. This study aims to determine the factors associated with TB status in PLHIV after ART initiation using HIV AIDS Information System (SIHA) 2.1 data. The design of this study was cross sectional with a sample of population aged ≥ 15 years utilizing HIV AIDS Information System data in 2023 and using chi-square test for bivariate analysis and logistic regression for multivariate analysis. Of the 39,623 PLHIV recorded in 2023, 34,662 data were eligible to be used in this study. The results showed that the region with the highest prevalence of HIV cases in DKI Jakarta was Central Jakarta (30.8%) while the region with the highest prevalence of HIV-TB was West Jakarta (25.1%). Furthermore, the prevalence of HIV-TB in the population ≥ 15 years old in DKI Jakarta after ART initiation was found to be 4.4%. Clinical stage 3 and 4 (AOR = 9.99; 95% CI = 8.72 - 11.45), lean body mass index (BMI) (AOR = 2.54; 95% CI = 2.22 - 2.91), age group 25 - 34 years (AOR = 2.16; 95% CI = 1.86 - 2.52), not taking Tuberculosis Preventive Therapy (TPT) (AOR = 17.73; 95% CI = 10.42 - 30.18) are risk factors that increase the presence of TB status in PLHIV. In addition, the protective factors for TB status among PLHIV were delayed initiation of antiretroviral therapy (ART) (AOR = 0.10; 95% CI = 0.09 - 0.12) and key population groups (AOR = 0.44; 95% CI = 0.39 - 0.51). The factor with the largest contribution in this study was history of TPT consumption. Thus, there is a need to increase TPT coverage to prevent TB status in PLHIV and young adult PLHIV are expected to improve TB prevention.
S-11620
Depok : FKM-UI, 2024
S1 - Skripsi Pusat Informasi Kesehatan Masyarakat
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Dessi Marantika Nilam Sari; Pembimbing: Mondastri Korib Sudaryo; Penguji: Syahrizal, Helwiah Umniyati, Suyono
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Kurangnya kepatuhan terhadap pengobatan menjadi faktor risiko munculnya jenis HIV yang resisten terhadap obat, yang dapat ditularkan kepada orang lain. Kepatuhan terhadap pengobatan yang buruk tidak hanya membahayakan kesehatan individu tetapi juga meningkatkan penularan. Penelitian ini bertujuan untuk mengamati faktor-faktor yang berhubungan dengan terjadinya ketidakpatuhan minum obat ARV pada ODHIV yang mendapatkan terapi ARV di Rumah Sakit Umum Daerah Kabupaten Tangerang. Jenis penelitian ini menggunakan penelitian observasional dengan rancangan cross sectional. Penelitian dilakukan di poli HIV Rumah Sakit Umum Daerah Kabupaten Tangerang dan waktu penelitian dilakukan pada bulan November 2023 menggunakan data sekunder. Populasi penelitian berjumlah 1.337 ODHIV yang aktif menjalani pengobatan antiretroviral di Rumah Sakit Umum Daerah Kabupaten Tangerang dengan menggunakan total sampling sesuai dengan kriteria inklusi dan ekslusi sehingga sampel penelitian berjumlah 1.286 ODHIV. Hasil analisis univariat menunjukan bahwa usia ≥ 35 tahun (56,45), laki-laki (61,20%), pendidikan rendah (87,10%), belum kawin atau cerai (51,92%), domisili dalam kabupaten Tangerang (55,88%), mendapatkan konseling kepatuhan (63,73%), memiliki jaminan kesehatan (51,92%), ≥5km akses layanan kesehatan (54,07%), IO non TB (40,90%), stadium lanjut (63,69%), viral load ≥40 mL (46,73%), tidak ada efek samping obat (53,34%), lamanya pengobatan >5 tahun (72,01%), masuk kedalam populasi kunci (88,01%) dan tidak mendapat dukungan (61,12%). Hasil analisis kai kuadrat secara statistik ada hubungan antara umur, jenis kelamin, status pendidikan, status perkawinan, domisili, pelayanan konseling kepatuhan, stadium klinis WHO, viral load, lamanya pengobatan ARV, kelompok populasi kunci dan dukungan teman sebaya (P-Value<0,05) dengan ketidakpatuhan minum obat ARV. Hasil analisis cox regression dengan faktor yang secara statistik berhubungan terhadap ketidakpatuhan minum obat antiretroviral pada ODHIV adalah umur (P-Value=0,01) nilai PR 1,20 dengan 95% CI (1,05-1,38), status perkawinan (P-Value=0,02) nilai PR 1,18 dengan 95% CI (1,03-1,36), domisili (P-Value=0,01) nilai PR 1,19 dengan 95% CI (1,04-1,36), viral load (P-Value=0,001) nilai PR 1,27 dengan 95% CI (1,10-1,43), lamanya pengobatan ARV (P-Value=0,005) nilai PR 1,25 dengan 95% CI (1,07-1,47), kelompok populasi kunci (P-Value=0,02) nilai PR 1,27 dengan 95% CI (1,04-1,56), dukungan teman sebaya (P-Value=0,04) nilai PR 1,15 dengan 95% CI (1,00-1,32). Faktor umur, status perkawinan, domisili, viral load, lamanya pengobatan, kelompok populasi kunci dan dukungan teman sebaya memiliki pengaruh terhadap ketidakpatuhan minum obat antiretroviral (ARV) pada ODHIV di Rumah Sakit Umum Daerah Kabupaten Tangerang.
Lack of treatment adherence becomes a risk factor for the emergence of drug-resistant strains of HIV, which can be transmitted to others. Poor adherence to treatment harms the individual’s health and increases the risk of transmission. This study aims to observe the factors associated with the occurrence of non-adherence to taking ARV drugs in PLHIV who receive ARV therapy at the Regional General Hospital of Tangerang Regency. This type of study uses observational research with a cross-sectional design. The study was conducted at the HIV Specialist of the Regional Govern Hospital of Tangerang Regency and the time of the study was carried out in November 2023 using secondary data. The study population amounted to 1,337 PLHIV who were actively undergoing antiretroviral treatment at the Regional General Hospital of Tangerang Regency using total sampling by inclusion and exclusion criteria so that the study sample amounted to 1,286 PLHIV. The results of the univariate analysis showed that the age of ≥ 35 years (56.45), male (61.20%), low education (87.10%), unmarried or divorced (51.92%), domiciled in Tangerang district (55.88%), received compliance counselling (63.73%), had health insurance (51.92%), ≥5km of health service access area (54.07%), non-TB IO (40.90%), advanced stage (63.69%), viral load ≥40 mL (46.73%), no drug side effects (53.34%), duration of treatment ≥5 years (72.01%), entered into key populations (88.01%) and received no support (61.12%). The results of the kai squared analysis statistically showed there was an association between age, sex, educational status, marital status, domicile, adherence to counselling services, WHO clinical stage, viral load, duration of ARV treatment, key population groups and peer support (P-Value<0.05) with non-adherence to taking ARV drugs. The results of Cox Regression analysis with factors statistically related to non-adherence to taking antiretroviral drugs in ODHIV were age (P-Value = 0.01), PR value 1.20 with 95% CI (1.05-1.38), marital status (P-Value = 0.02), PR value 1.18 with 95% CI (1.03-1.36), domicile (P-Value = 0.01), PR value 1.19 with 95% CI (1.04-1.36), viral load (P-Value = 0.001), PR value 1.27 with 95% CI (1.10-1.43), duration of ARV treatment (P-Value = 0.005), PR value 1.25 with 95% CI (1.07-1.47), key population group (P-Value = 0.02), PR value 1.27 with 95% CI (1.04-1.56), peer support (P-Value = 0.04), PR value 1.15 with 95% CI (1.00-1.32). Factors such as age, marital status, domicile, viral load, duration of treatment, key population groups and peer support have an influence on non-adherence to taking antiretroviral drugs (ARV) in PLHIV at the Regional General Hospital of Tangerang Regency.
T-6876
Depok : FKM-UI, 2024
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Lily Banonah Rivai; Pembimbing: Lukman Hakim Tarigan; Penguji: Ratna Djuwita, Indang Trihandini, Janto G. Lingga, Dyah Erty Mustikawati
T-3032
Depok : FKM UI, 2008
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Qania Faradillah Arumdias; Pembimbing: Soedarto Ronoatmodjo; Penguji: Ratna Djuwita, Ismelya
S-10238
Depok : FKM UI, 2019
S1 - Skripsi Pusat Informasi Kesehatan Masyarakat
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Neneng Aini; Pembimbing: Syahrizal Syarif; Penguji: Mondastri Korib Sudaryo, Herman Kosasih
Abstrak:
Terapi antiretroviral mampu menekan replikasi HIV, mencegah morbilitas dan mortalitas. Kepatuhan pengobatan dibutuhkan untuk mencapai kesuksesan terapi, mencegah resistensi obat antiretroviral dan risiko penularan HIV ditengah masyarakat. Penelitian ini bertujuan untuk mengetahui factor-faktor yang mempengaruhi kepatuhan pengobatan obat antiretroviral pasien HIV/AIDS di empat rumah sakit di DKI Jakarta tahun 20182019. Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional dari data baseline penelitian INA-PROACTIVE (data sekunder). dimana sebanyak 666 ODHA dipilih sebagai sampel. Kepatuhan pengobatan diukur berdasarkan self report. Data dianalisa dengan menggunakan cox proportional hazard regression dengan perangkat lunak STATA12. Hasil penelitian menunjukkan proporsi kepatuhan <95% sebesar 17,9%. Analisis faktor determinan kepatuhan berobat pada penelitian ini menggunakan analisis multivariat cox regresi dan besar pengaruh dinyatakan dalam prevalensi rasio (PR) dengan confident interval (CI) 95%. Penelitian ini menunjukkan faktor sosio-demografi yang berhubungan dengan ketidakpatuhan pengobatan pada ODHA yang mendapat terapi ARV adalah variabel jenis kelamin, usia, status pernikahan dan rute transmisi HIV. Faktor klinis yang mempunyai hubungan dengan kepatuhan minum obat ARV adalah variabel adanya riwayat infeksi oportunistik sifilis dan nilai CD4. Faktor pengobatan yang mempunyai hubungan dengan kepatuhan minum obat ARV adalah variabel jenis paduan ARV dan lama pengobatan ARV. Semua variabel tersebut tidak berpengaruh signifkan secara statistik dengan nilai p value > 0,05
Antiretroviral therapy suppresses HIV replication, prevent mobility and mortality. Treatment adherence is needed to achieve therapeutic success, prevent antiretroviral drug resistance and the risk of HIV transmission in the community. This study aims to determine the factors that associated with the adherent of antiretroviral drug treatment of HIV / AIDS patients in four hospitals in Jakarta in 2018-2019. This study was an observational study with a cross sectional design from the baseline data of INAPROACTIVE study (secondary data) from 666 people living with HIV. Treatment compliance was measured by self-report. Data were analyzed using cox proportional hazard regression with STATA12 software. The results showed the proportion of nonadherent by 17.9%, Analysis of determinant factors for compliance with treatment in this study using multivariate cox regression analysis and the magnitude of the effect was expressed in the prevalence ratio (PR) with 95% confidence interval (CI). Our study showed a proportion of ARV treatment adherence ≥ 95% showed 82.1%. This study showed that the socio-demographic factors associated with ARV treatment adherence among people living with HIV who received ARV therapy were gender, age, marital status and HIV transmission route. Clinical factors that have a relationship with adherence of ARV were the variable history of opportunistic infection syphilis and CD4 value. Treatment factors that have a relationship with adherence of ARV were the variable type of ARV regiment and duration of ARV treatment. All these variables were not statistially significant effect with p value > 0.05.
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Antiretroviral therapy suppresses HIV replication, prevent mobility and mortality. Treatment adherence is needed to achieve therapeutic success, prevent antiretroviral drug resistance and the risk of HIV transmission in the community. This study aims to determine the factors that associated with the adherent of antiretroviral drug treatment of HIV / AIDS patients in four hospitals in Jakarta in 2018-2019. This study was an observational study with a cross sectional design from the baseline data of INAPROACTIVE study (secondary data) from 666 people living with HIV. Treatment compliance was measured by self-report. Data were analyzed using cox proportional hazard regression with STATA12 software. The results showed the proportion of nonadherent by 17.9%, Analysis of determinant factors for compliance with treatment in this study using multivariate cox regression analysis and the magnitude of the effect was expressed in the prevalence ratio (PR) with 95% confidence interval (CI). Our study showed a proportion of ARV treatment adherence ≥ 95% showed 82.1%. This study showed that the socio-demographic factors associated with ARV treatment adherence among people living with HIV who received ARV therapy were gender, age, marital status and HIV transmission route. Clinical factors that have a relationship with adherence of ARV were the variable history of opportunistic infection syphilis and CD4 value. Treatment factors that have a relationship with adherence of ARV were the variable type of ARV regiment and duration of ARV treatment. All these variables were not statistially significant effect with p value > 0.05.
T-6120
Depok : FKM-UI, 2021
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Sonya Audrelianti Rizal; Pembimbing: Tri Yunis Miko Wahyono; Penguji: Putri Bungsu, Haridana Indah Setiawati Mahdi
Abstrak:
Human Immunodeficiency Virus (HIV) merupakan jenis retrovirus yang menginfeksi dan merusak sel imun dalam tubuh penderita. Virus ini menyerang dan bermultiplikasi pada sel limfosit CD4 hingga melemahkan dan menghancurkan sistem imun tersebut. HIV yang tidak tertangani akan menyebabkan AIDS (acquired immunodeficiency syndrome) yang menyebabkan tuberculosis, diabetes melitus, dan kanker. Menurut Kementerian Kesehatan RI pada tahun 2022 terdapat 90.956 kasus HIV dengan 28.501 kasus kematian. Kanker merupakan penyakit yang umum terjadi pada pasien HIV dimana pasien HIV 50-200 kali lebih tinggi dibandingkan individu yang sehat sehingga muncul kepentingan untuk menekan angka terjadinya kanker melalui beberapa upaya seperti pengadaan layanan konseling HIV, melakukan pengobatan ART dan skrining infeksi oportunistik. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berasosiasi dengan kejadian kanker pada ODHIV menggunakan data rekam medis Rumah Sakit Kanker Dharmais. Penelitian ini dilakukan dengan desain studi cross sectional. Analisis data dilakukan secara univariat dan bivariat menggunakan chi-square dan menampilkan nilai prevalence ratio (95% CI). Berdasarkan analisis, terdapat hubungan yang signifikan antara total CD4, jenis kelamin, dan infeksi oportunistik di Rumah Sakit Kanker Dharmais OR total CD4 <200 3,843 (95% CI 1,741-8,484), OR total CD4 200-499 0,595 (95% CI 0,348-1,007), OR ODHIV perempuan sebesar 0,447 (95% CI 0,271-0,738) dan OR ODHIV dengan infeksi oportunistik 0,327 (95% CI 0,248-0,431).
Human Immunodeficiency Virus (HIV) is a type of retrovirus that infects and damages immune cells in the body. This virus targets and multiplies within CD4 lymphocyte cells, weakening and eventually destroying the immune system. Untreated HIV leads to acquired immunodeficiency syndrome (AIDS), which is associated with opportunistic infections such as tuberculosis, diabetes mellitus, and cancer. According to the Indonesian Ministry of Health, in 2022 there were 90,956 HIV cases with 28,501 deaths reported. Cancer is a common disease among HIV patients, who have a 50-200 times higher risk compared to healthy individuals, highlighting the need to reduce cancer incidence through efforts such as providing HIV counselling services, administering ART treatment, and screening for opportunistic infections. This study aims to identify factors associated with cancer incidence in PLHIV using medical record data from Dharmais Cancer Hospital. The research employs a cross-sectional study design. Data analysis was conducted using univariate and bivariate methods, with chi-square tests and prevalence ratios (95% CI) presented. Based on the analysis, significant associations were found between total CD4 count, gender, and opportunistic infections. At Dharmais Cancer Hospital, the relative risk (OR) for total CD4 <200 was 3.843 (95% CI 1.741-8.484), for total CD4 200-499 was 0.595 (95% CI 0.348-1.007), for female PLHIV was 0.447 (95% CI 0.271-0.738), and for PLHIV with opportunistic infections was 0.327 (95% CI 0.248-0.431).
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Human Immunodeficiency Virus (HIV) is a type of retrovirus that infects and damages immune cells in the body. This virus targets and multiplies within CD4 lymphocyte cells, weakening and eventually destroying the immune system. Untreated HIV leads to acquired immunodeficiency syndrome (AIDS), which is associated with opportunistic infections such as tuberculosis, diabetes mellitus, and cancer. According to the Indonesian Ministry of Health, in 2022 there were 90,956 HIV cases with 28,501 deaths reported. Cancer is a common disease among HIV patients, who have a 50-200 times higher risk compared to healthy individuals, highlighting the need to reduce cancer incidence through efforts such as providing HIV counselling services, administering ART treatment, and screening for opportunistic infections. This study aims to identify factors associated with cancer incidence in PLHIV using medical record data from Dharmais Cancer Hospital. The research employs a cross-sectional study design. Data analysis was conducted using univariate and bivariate methods, with chi-square tests and prevalence ratios (95% CI) presented. Based on the analysis, significant associations were found between total CD4 count, gender, and opportunistic infections. At Dharmais Cancer Hospital, the relative risk (OR) for total CD4 <200 was 3.843 (95% CI 1.741-8.484), for total CD4 200-499 was 0.595 (95% CI 0.348-1.007), for female PLHIV was 0.447 (95% CI 0.271-0.738), and for PLHIV with opportunistic infections was 0.327 (95% CI 0.248-0.431).
S-11865
Depok : FKM UI, 2025
S1 - Skripsi Pusat Informasi Kesehatan Masyarakat
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