Ditemukan 3 dokumen yang sesuai dengan query :: Simpan CSV
Bonita Effendi; Pembimbing: Mondastri Korib Sudaryo; Penguji: Ratna Djuwita, Hedirman T. Pohan, Soewarta Kosen
T-4659
Depok : FKM-UI, 2016
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Fahrul Islam; Pembimbing: Budi Hartono, Laila Fitria; Penguji: Ririn Arminsih Wulandari, Didik Supriyono, Sonny Priajaya Warouw
Abstrak:
Kromium adalah logam berat yang banyak digunakan dalam kegiatan industri.Penggunaan kromium pada industri pelapisan logam dapat berisiko terhadap kesehatanpekerja yang berasal dari pajanan kromium di udara lingkungan kerja. Penelitian inibertujuan untuk menganalisis hubungan kadar kromium dalam urin dengan kadaralbumin dalam urin sebagai biomarker kerusakan ginjal. Penelitian ini dilakukan pada33 pekerja terpajan dan 33 pekerja tidak terpajan dengan sedain cross sectional. Sampelurin diambil untuk menilai kadar kromium dan kadar albumin. Kadar kromium dalamurin diukur menggunakan metode metode Atomic Absorption Spectrometry (AAS)dengan teknik pembakaran (flame, FAAS) dan kadar albumin dalam urin di ukurdengan cara immunoturbidimetric assay. Nilai tengah (median) kadar kromium dalamurin pada pekerja terpajan sebesar 5 μg/L dan pada pekerja tidak terpajan juga sebesar5 μg/L. Nilai tengah (median) kadar albumin dalam urin pada pekerja terpajan sebesar2,5 mg/g kreatinin lebih tinggi dari kadar albumin pada pekerja tidak terpajan yaitusebesar 1,5 mg/g kreatinin. Setiap kenaikan kadar kromium 1 μg/L terjadi kenaikankadar albumin sebesar 3,82 mg/g kreatinin setelah dikontrol variabel riwayat diabetes,riwayat hipertensi, kebiasaan merokok, lama kerja, dan konsumsi alkohol. Hasilpenelitian dapat disimpulkan ada pengaruh pajanan kromium dengan gangguan fungsiginjal (p > 0,05).Kata kunci; albumin, kerusakan ginjal, kromium, pelapisan logam
Chromium is a heavy metal that is widely used in industrial activities. Use of chromiumin the metal plating industry pose a risk to workers' health comes from exposure tochromium in the air working environment. This study aimed to analyze the relationshipbetween chromium levels in urine levels of albumin in the urine as a biomarker ofkidney damage. This study was conducted on 33 workers exposed and 33 unexposedworkers with cross sectional sedain. Urine samples were taken to assess levels ofchromium and albumin. Chromium levels in urine were measured using the methodAtomic Absorption Spectrometry (AAS) with burning techniques (flame, FAAS) andalbumin in urine is measured by means of immunoturbidimetric assay. A middle value(median) level of chromium in the urine of workers exposed at 5 g / L and theunexposed workers are also at 5 ug / L. A middle value (median) level of albumin inthe urine in workers exposed at 2.5 mg / g creatinine higher than the levels of albuminin the unexposed workers is equal to 1.5 mg / g creatinine. Any increase in thechromium content of 1 ug / L occurred rising levels of 3,82 mg albumin / g creatinineafter the controlled variable history of diabetes, history of hypertension, smokinghabits, length of employment, and consumption of alcohol. The results of this studyconcluded there was an effect of chromium exposure with impaired renal function (p>0.05).Keywords; albumin, kidney damage, chromium, electroplating.
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Chromium is a heavy metal that is widely used in industrial activities. Use of chromiumin the metal plating industry pose a risk to workers' health comes from exposure tochromium in the air working environment. This study aimed to analyze the relationshipbetween chromium levels in urine levels of albumin in the urine as a biomarker ofkidney damage. This study was conducted on 33 workers exposed and 33 unexposedworkers with cross sectional sedain. Urine samples were taken to assess levels ofchromium and albumin. Chromium levels in urine were measured using the methodAtomic Absorption Spectrometry (AAS) with burning techniques (flame, FAAS) andalbumin in urine is measured by means of immunoturbidimetric assay. A middle value(median) level of chromium in the urine of workers exposed at 5 g / L and theunexposed workers are also at 5 ug / L. A middle value (median) level of albumin inthe urine in workers exposed at 2.5 mg / g creatinine higher than the levels of albuminin the unexposed workers is equal to 1.5 mg / g creatinine. Any increase in thechromium content of 1 ug / L occurred rising levels of 3,82 mg albumin / g creatinineafter the controlled variable history of diabetes, history of hypertension, smokinghabits, length of employment, and consumption of alcohol. The results of this studyconcluded there was an effect of chromium exposure with impaired renal function (p>0.05).Keywords; albumin, kidney damage, chromium, electroplating.
T-4628
Depok : FKM-UI, 2016
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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Miptah Farid Thariqulhaq; Pembimbing: Tri Yunis Miko Wahyono; Penguji: Ratna Djuwita, Neni Sawitri, Meilina Farikha
Abstrak:
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Penyakit TB MDR merupakan salah satu penyakit infeksi yang prevalensinya semakin meningkat dari tahun ke tahun di Indonesia dengan angka keberhasilan pengobatan 45%. Konversi kultur sputum merupakan suatu prediktor kuat dari awal keberhasilan terapi. Waktu konversi yang lambat akan memperpanjang periode penularan dan memprediksi tingkat kegagalan pengobatan yang tinggi. Terdapat beberapa faktor risiko yang berhubungan dengan konversi kultur sputum pasien TB MDR. Penelitian terkait faktor risiko kadar albumin dengan waktu konversi kultur sputum masih sangat terbatas. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar albumin dengan waktu konversi kultur sputum di poli MDR terpadu RS Paru Dr M Goenawan Partowidigdo tahun 2022. Penelitian ini menggunakan studi cohort retrospektif dengan sampel yang diambil dari catatan rekam medis dan SITB pasien poli MDR. Variabel yang diteliti adalah kadar albumin < 3,5 gram/dl dan ≥ 3,5 gram/dl dengan variabel covariat usia, jenis kelamin, pendidikan, index masa tubuh, status merokok, gradasi sputum bta, komorbid, regimen pengobatan, dan kepatuhan minum obat . Hasil penelitian berdasarkan analisis multivariat menunjukkan kadar albumin < 3,5 mg/dl memiliki kecepatan waktu konversi 41,8% lebih lambat dengan (HR=0,582, 95% CI 0.344-0.984) untuk mengalami konversi dibanding dengan pasien TB MDR dengan kadar albumin ≥ 3,5 mg/dl setelah memperhitungkan status merokok dan kepatuhan minum obat. Perlunya memperbaiki kadar albumin yang rendah pada pasien TB MDR di rumah sakit dan memberikan penyuluhan kepada keluarga pasien agar turut berpartisipasi memantau asupan makan pasien yaitu makanan yang mengandung tinggi protein seperti ikan gabus serta ekstra putih telur untuk membantu meningkatkan kadar albumin pasien yang dapat berguna untuk terjadinya konversi kultur sputum.
MDR TB disease is an infectious disease whose prevalence is increasing from year to year in Indonesia with a treatment success rate of 45%. Sputum culture conversion is a strong predictor of initial therapeutic success. Slow conversion time will prolong the period of transmission and predict a high rate of treatment failure. There are several risk factors associated with sputum culture conversion in MDR TB patients. Research related to risk factors for albumin levels and sputum culture conversion time is still very limited. The aim of this study was to determine the relationship between albumin levels and sputum culture conversion time at the integrated MDR polyclinic at Dr M Goenawan Partowidigdo Pulmonary Hospital in 2022. This study used a retrospective cohort study with samples taken from medical records and SITB patients at poly MDR. The variables studied were albumin levels < 3.5 mg/dl and ≥ 3.5 mg/dl with the covariate variables age, sex, education, body mass index, smoking status, sputum gradation, co-morbidities, medication regimens, and drinking adherence drug . The results of the study based on multivariate analysis showed that albumin levels < 3.5 mg/dl had a 41.8% slower conversion time (HR=0.582, 95% CI 0.344-0.984) to experience conversion compared to MDR TB patients with albumin levels ≥ 3.5 mg/dl after taking into account smoking status and medication adherence. It is necessary to improve low albumin levels in MDR TB patients at the hospital and provide counseling to the patient's family to participate in monitoring the patient's food intake, namely foods that contain high protein such as snakehead fish and extra egg whites to help increase the patient's albumin levels which can be useful for the occurrence of sputum culture conversion.
T-6801
Depok : FKM-UI, 2023
S2 - Tesis Pusat Informasi Kesehatan Masyarakat
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