Latar Belakang: Resistensi Antimikroba merupakan ancaman global yang berdampak pada peningkatan morbiditas, mortalitas, serta biaya perawatan Kesehatan. RS Hermina Jatinegara adalah RS swasta yang ditetapkan tepe B dengan layanan Umum sebagai RS pelayanan rujukan memiliki peran penting dalam mencegah resistensi melalui Implementasi Program Pengendalian Resistensi Antimikroba (PPRA). RS Hermina Jatinegara telah memiliki komponen utama PPRA seperti Kebijakan PPRA, Pedoman penggunaan antibiotic, Tim PPRA, Kebijakan pengelompokan antibiotic AWaRe, serta system persetujuan antibiotic melalui E-RASPRO. Tujuan penelitian: secara umum Adalah Menganalisis implementasi PPRA, mengoptimalkan peran manajemen rumah sakit dalam mendukung penggunaan antibiotik secara bijak, dan strategi pengelolaan di Rumah Sakit Hermina Jatinegara, secara khusus adalah menganalisis penerapan pedoman dan kebijakan penggunaan antibiotik, tingkat kepatuhan tenaga medis terhadap pedoman penggunaan antibiotik, evaluasi efektivitas sistem monitoring dan evaluasi penggunaan antibiotik, peran manajemen rumah sakit dalam mendukung pelaksanaan PPRA, dan strategi perbaikan untuk meningkatkan efektivitas PPRA dan mutu pelayanan rumah sakit. Metode penelitian: Penelitian ini menggunakan desain kualitatif melalui wawancan mendalam dengan manajemen RS, dokter, perawat, apoteker, dan Tim PPRA, FGD, serta telaah dokumen. Penelitian ini juga menggunakan data sekunder berupa data farmasi data peresepan, Laporan monitoring evaluasi PPRA yang didalamnya terdapat kepatuhan terhadap PPAB dan data resistensi kuman dari data mikrobiologi. Hasil penelitian: Hasil penelitian menunjukkan bahwa regulasi PPRA di RS Hermina Jatinegara telah lengkap, termasuk PPAB, SK Tim PPRA, AWaRe, dan mekanisme persetujuan antibiotik melalui E-RASPRO. Namun implementasinya belum seragam di seluruh unit. Ketidaksesuaian penggunaan antibiotik ditemukan pada aspek durasi, indikasi, dan dokumentasi. Audit belum rutin dilakukan dan belum mencakup seluruh kasus prioritas. Integrasi data kultur ke dalam E-RASPRO belum optimal. Ketersediaan antibiogram belum representatif karena keterbatasan sampel kultur dan SDM mikrobiologi. Laporan PPRA telah dibuat secara berkala per triwulan, tetapi belum memuat indikator lengkap seperti Days Of Therapy (DOT), IV-to-PO, dan audit umpan balik. Kesimpulan: Implementasi PPRA di RS Hermina Jatinegara sudah berjalan namun belum optimal. Penguatan pembiayaan, kapasitas sampel mikrobiologi, kajian/audit rutin, integrasi data, serta pelatihan semua profesi diperlukan untuk meningkatkan konsistensi dan keberhasilan implementasi PPRA.

Background: Antimicrobial resistance is a global threat that has an impact on increased morbidity, mortality, and healthcare costs. Hermina Jatinegara Hospital is a private hospital designated as a type B hospital with general services as a referral hospital that plays an important role in preventing resistance through the implementation of the Antimicrobial Resistance Control Program (PPRA). Hermina Jatinegara Hospital has established key components of the PPRA, including PPRA policies, antibiotic usage guidelines, PPRA team, antibiotic grouping policies under the AWaRe framework, and an antibiotic approval system via E-RASPRO. Research Objectives: To analyze the implementation of the AMCP, optimize the role of hospital management in supporting prudent antibiotic use, and management strategies at Hermina Jatinegara Hospital. Specifically, it aims to analyze the implementation of guidelines and policies on antibiotic use, the level of compliance of medical personnel with antibiotic use guidelines, evaluate the effectiveness of the antibiotic use monitoring and evaluation system, the role of hospital management in supporting the implementation of PPRA, and improvement strategies to increase the effectiveness of PPRA and the quality of hospital services. Research method: This study used a qualitative design through in-depth interviews with hospital management, doctors, nurses, pharmacists, and the PPRA Team, FGDs, and document reviews. This study also used secondary data in the form of pharmacy prescription data, PPRA monitoring and evaluation reports containing compliance with PPAB, and germ resistance data from microbiology data. Research results: The results showed that PPRA regulations at Hermina Jatinegara Hospital were complete, including PPAB, PPRA Team Decree, AWaRe, and the antibiotic approval mechanism through E- RASPRO. However, implementation was not uniform across all units. Inappropriate antibiotic use was found in terms of duration, indication, and documentation. Audits have not been conducted routinely and do not cover all priority cases. The integration of culture data into E-RASPRO is not yet optimal. The availability of antibiograms is not representative due to limitations in culture samples and microbiology human resources. PPRA reports have been prepared quarterly, but do not yet include complete indicators such as Days Of Therapy (DOT), IV-to-PO, and feedback audits. Conclusion: The implementation of PPRA at Hermina Jatinegara Hospital is underway but is not yet optimal. Strengthening of funding, microbiology sample capacity, routine reviews/audits, data integration, and training for all professions are needed to improve the consistency and success of PPRA implementation.

Persediaan obat yang tidak optimal di rumah sakit dapat berdampak serius terhadap mutu pelayanan kesehatan, efisiensi operasional, dan keselamatan pasien. Salah satu permasalahan yang sering terjadi adalah kekosongan obat, termasuk antibiotik, yang dapat menyebabkan penundaan pengobatan, peningkatan risiko resistensi, serta kerugian finansial akibat back order dan kehilangan penjualan. RS Jakarta sebagai rumah sakit swasta tipe C mengalami 98 kejadian obat kosong selama periode Januari 2024 hingga Maret 2025, dengan 16 kejadian di antaranya adalah kekosongan antibiotik. Penelitian ini bertujuan untuk menganalisis pengendalian persediaan antibiotik di Instalasi Farmasi RS Jakarta menggunakan metode kombinasi ABC-VEN, serta menghitung kebutuhan safety stock dan reorder point (ROP).  Penelitian ini menggunakan desain operational research dengan pendekatan kuantitatif deskriptif. Data yang digunakan terdiri dari data sekunder selama April 2024 hingga Maret 2025, dan data primer berupa hasil kuesioner VEN. Antibiotik dalam penelitian ini dibagi menjadi kategori reguler dan mata sesuai dengan sediaan. Analisis dilakukan dalam beberapa tahap: analisis ABC nilai investasi, analisis VEN, dan kombinasi analisis ABC-VEN. Selanjutnya dilakukan perhitungan safety stock dan ROP untuk setiap item antibiotik. Evaluasi kinerja dilakukan dengan membandingkan nilai persediaan dan ITOR sebelum dan setelah simulasi perhitungan. Simulasi menunjukkan penurunan nilai persediaan hingga berkisar 28 juta rupiah hingga 62 juta rupiah per bulan, atau sekitar 27%-59% dari persediaan aktual. Selain itu hasil simulasi menunjukan peningkatan nilai ITOR berkisar antara 0,68 hingga 2,66. Maka dapat disimpulkan, metode kombinasi ABC-VEN yang dikombinasikan dengan perhitungan safety stock dan ROP terbukti efektif dalam mengoptimalkan perencanaan persediaan antibiotik di RS Jakarta. 

Inefficient drug inventory management in hospitals can have serious implications for service quality, operational efficiency, and patient safety. A frequent issue is stock-outs, particularly of antibiotics, which may lead to delays in treatment, heightened risk of antimicrobial resistance, and financial losses due to back orders and missed sales opportunities. RS Jakarta, a private Type C hospital, recorded 98 stock-out events between January 2024 and March 2025, 16 of which involved antibiotics. This study aims to evaluate the management of antibiotic inventory at the Pharmacy Department of RS Jakarta by applying the combined ABC-VEN classification method, alongside calculations of safety stock and reorder points (ROP). The study adopts an operational research design with a descriptive quantitative approach. Data sources include secondary data collected from April 2024 to March 2025 and primary data obtained through a VEN classification questionnaire. Antibiotics were categorized into regular and ophthalmic groups based on their dosage forms. The analysis consisted of several steps: ABC analysis based on investment value, VEN categorization, and the integration of both into a combined ABC-VEN matrix. Subsequently, safety stock and ROP were calculated for each antibiotic item. Output  was evaluated by comparing inventory value and the Inventory Turnover Ratio before and after simulation. The simulation results indicated a monthly reduction in inventory value ranging from approximately IDR 28 million to IDR 62 million, representing a 27%–59% decrease compared to the actual inventory. Furthermore, the ITOR values increased by a range of 0.68 to 2.66. These findings suggest that the integration of the ABC-VEN method with safety stock and ROP calculations is an effective strategy for optimizing antibiotic inventory planning at RS Jakarta.