Abstrak: The short-term association between diarrhea and weight is well-accepted, but the long-term association between diarrhea and growth is less clear. Using data from 7 cohort studies (Peru, 1985-1987; Peru, 1989-1991; Peru, 1995-1998; Brazil, 1989-1998; Guinea-Bissau, 1987-1990; Guinea-Bissau, 1996-1997; and Bangladesh, 1993-1996), we evaluated the lagged relationship between diarrhea and growth in the first 2 years of life. Our analysis included 1,007 children with 597,638 child-days of diarrhea surveillance and 15,629 anthropometric measurements. We calculated the associations between varying diarrhea burdens during lagged 30-day periods and length at 24 months of age. The cumulative association between the average diarrhea burden and length at age 24 months was -0.38 cm (95% confidence interval: -0.59, -0.17). Diarrhea during the 30 days prior to anthropometric measurement was consistently associated with lower weight at most ages, but there was little indication of a short-term association with length. Diarrhea was associated with a small but measurable decrease in linear growth over the long term. These findings support a focus on prevention of diarrhea as part of an overall public health strategy for improving child health and nutrition; however, more research is needed to explore catch-up growth and potential confounders.

Abstrak: Malnutrisi merupakan permasalahan gizi pada hemodialisis dengan prevalensi berkisar antara 50 - 70 % dan penelitian tahun 2018 di RSCM menyebutkan prevalensi malnutrisi sebesar 39%. Tesis ini bertujuan mengetahui determinan penilaian Malnutrition Inflammation Score (MIS) penyakit ginjal kronis hemodialisis di RSUPN Dr. Cipto Mangunkusumo. Penelitian ini merupakan penelitian payung Departemen Ilmu Penyakit Dalam Unit Ginjal Hipertensi RSCM menggunakan desain Cross Sectional, data primer dikumpulkan pada bulan Februari dan Mei 2018. Besar sampel menggunakan uji hipotesis populasi dengan total sampel 120 pasien. Pengumpulan data menggunakan kuesioner, data diperoleh melalui wawancara dan data laboratorium diperoleh melalui rekam medis, kemudian Editing, Coding, Processing dan Cleaning, dilakukan analisis univariat, bivariat dan multivariat untuk melihat faktor determinan yang berpengaruh dengan MIS Simpulan penelitian prevalensi malnutrisi inflamasi pasien hemodialisis sebesar 55,8%, Jenis kelamin laki-laki memiliki risiko 4,1 malnutrisi, usia ≥40 tahun memiliki risiko 3,1, asupan protein kurang berisiko 2,8 kali dan kekuatan genggam kurang sebagai variabel protektif memiliki risiko lebih rendah 0,23 kali. Hasil penelitian diharapkan dapat memberikan manfaat untuk proses pelayanan asuhan gizi dan program intervensi gizi pasien hemodialisis