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Tuberculosis is still a major cause of health problems and death in the worldwide. The prevalence of DM which continues to increase each year is estimated to be in 2045, there are 629 million people who will suffer from diabetes. This study aims to assess the association DM on TB treatment failure in TB patients in 2017-2019 in Indonesia. Method. This study was conducted using a retrospective cohort study design. The population and sample of this study were all drug-sensitive TB patients in Indonesia who started treatment in 2017-2019 and registered in the Integrated Tuberculosis Information System (SITT) that met the inclusion and exclusion criteria. Data analysis was performed using Cox Regression. Result. A total of 107036 TB patients were included in the analysis of 1,251,525 TB patients registered in 2017- 21019, of which 23388 (21.9%) TB DM patients. The characteristics of the majority of TB patients are aged 15-44 years (51.3%), male 59.8%, live in the district 58.8%, have positive sputum at the time of initial examination 64.8%, history of treatment new TB 94.09%, HIV negative (76.2%). Region of residence, baseline sputum examination, treatment history and HIV status were significantly associated with treatment failure. TBDM patients had 1.72 (95% CI; 1.51-1.95) times the risk of experiencing treatment failure than TBnonDM patients. The proportion of treatment failure of TBDM patients caused by the interaction of DM with treatment history is 50%. Multivariate analysis showed that the risk of treatment failure in TB DM ARR patients was 1.83 (95% CI; 1.6-2.09) compared with nonDM TB patients after being controlled by gender and sputum variables. Conclusion. DM increases the risk of treatment failure in TB patients so controlling blood sugar levels during treatment for TBDM patients is very necessary
Tuberculosis is still the main cause of death worldwide, including Indonesia as the 3rd country with the highest number of tuberculosis sufferers in the world. Meanwhile, at the provincial level, Depok City is in 11th place with the largest contributor to tuberculosis cases in West Java Province. This study aims to determine the relationship between healthy homes, TB treatment coverage, and TB treatment success rates with the Incidence Rate (IR) tuberculosis in Depok City in 2021. This study uses an ecological study design based on place with a population of all communities recorded in 11 sub-districts in Depok. Depok City, which was diagnosed with tuberculosis. The results of the study through the correlation test showed that the independent variables that had a significant relationship with the Incidence Rate (IR) of tuberculosis is treatment coverage in Bojongsari District (p = 0.000). Meanwhile, the results of the correlation test between healthy home coverage, TB treatment coverage, and TB treatment success rates in Depok City showed an insignificant relationship. The results of other analyzes showed that the coverage of healthy homes in Depok City had a weak negative correlation (r = -0.173), TB treatment coverage had a weak positive correlation (r = 0.184), and the success rate of TB treatment had a strong negative correlation (r = -0.584).
