Latar Belakang: Resistensi Antimikroba merupakan ancaman global yang berdampak pada peningkatan morbiditas, mortalitas, serta biaya perawatan Kesehatan. RS Hermina Jatinegara adalah RS swasta yang ditetapkan tepe B dengan layanan Umum sebagai RS pelayanan rujukan memiliki peran penting dalam mencegah resistensi melalui Implementasi Program Pengendalian Resistensi Antimikroba (PPRA). RS Hermina Jatinegara telah memiliki komponen utama PPRA seperti Kebijakan PPRA, Pedoman penggunaan antibiotic, Tim PPRA, Kebijakan pengelompokan antibiotic AWaRe, serta system persetujuan antibiotic melalui E-RASPRO. Tujuan penelitian: secara umum Adalah Menganalisis implementasi PPRA, mengoptimalkan peran manajemen rumah sakit dalam mendukung penggunaan antibiotik secara bijak, dan strategi pengelolaan di Rumah Sakit Hermina Jatinegara, secara khusus adalah menganalisis penerapan pedoman dan kebijakan penggunaan antibiotik, tingkat kepatuhan tenaga medis terhadap pedoman penggunaan antibiotik, evaluasi efektivitas sistem monitoring dan evaluasi penggunaan antibiotik, peran manajemen rumah sakit dalam mendukung pelaksanaan PPRA, dan strategi perbaikan untuk meningkatkan efektivitas PPRA dan mutu pelayanan rumah sakit. Metode penelitian: Penelitian ini menggunakan desain kualitatif melalui wawancan mendalam dengan manajemen RS, dokter, perawat, apoteker, dan Tim PPRA, FGD, serta telaah dokumen. Penelitian ini juga menggunakan data sekunder berupa data farmasi data peresepan, Laporan monitoring evaluasi PPRA yang didalamnya terdapat kepatuhan terhadap PPAB dan data resistensi kuman dari data mikrobiologi. Hasil penelitian: Hasil penelitian menunjukkan bahwa regulasi PPRA di RS Hermina Jatinegara telah lengkap, termasuk PPAB, SK Tim PPRA, AWaRe, dan mekanisme persetujuan antibiotik melalui E-RASPRO. Namun implementasinya belum seragam di seluruh unit. Ketidaksesuaian penggunaan antibiotik ditemukan pada aspek durasi, indikasi, dan dokumentasi. Audit belum rutin dilakukan dan belum mencakup seluruh kasus prioritas. Integrasi data kultur ke dalam E-RASPRO belum optimal. Ketersediaan antibiogram belum representatif karena keterbatasan sampel kultur dan SDM mikrobiologi. Laporan PPRA telah dibuat secara berkala per triwulan, tetapi belum memuat indikator lengkap seperti Days Of Therapy (DOT), IV-to-PO, dan audit umpan balik. Kesimpulan: Implementasi PPRA di RS Hermina Jatinegara sudah berjalan namun belum optimal. Penguatan pembiayaan, kapasitas sampel mikrobiologi, kajian/audit rutin, integrasi data, serta pelatihan semua profesi diperlukan untuk meningkatkan konsistensi dan keberhasilan implementasi PPRA.

Background: Antimicrobial resistance is a global threat that has an impact on increased morbidity, mortality, and healthcare costs. Hermina Jatinegara Hospital is a private hospital designated as a type B hospital with general services as a referral hospital that plays an important role in preventing resistance through the implementation of the Antimicrobial Resistance Control Program (PPRA). Hermina Jatinegara Hospital has established key components of the PPRA, including PPRA policies, antibiotic usage guidelines, PPRA team, antibiotic grouping policies under the AWaRe framework, and an antibiotic approval system via E-RASPRO. Research Objectives: To analyze the implementation of the AMCP, optimize the role of hospital management in supporting prudent antibiotic use, and management strategies at Hermina Jatinegara Hospital. Specifically, it aims to analyze the implementation of guidelines and policies on antibiotic use, the level of compliance of medical personnel with antibiotic use guidelines, evaluate the effectiveness of the antibiotic use monitoring and evaluation system, the role of hospital management in supporting the implementation of PPRA, and improvement strategies to increase the effectiveness of PPRA and the quality of hospital services. Research method: This study used a qualitative design through in-depth interviews with hospital management, doctors, nurses, pharmacists, and the PPRA Team, FGDs, and document reviews. This study also used secondary data in the form of pharmacy prescription data, PPRA monitoring and evaluation reports containing compliance with PPAB, and germ resistance data from microbiology data. Research results: The results showed that PPRA regulations at Hermina Jatinegara Hospital were complete, including PPAB, PPRA Team Decree, AWaRe, and the antibiotic approval mechanism through E- RASPRO. However, implementation was not uniform across all units. Inappropriate antibiotic use was found in terms of duration, indication, and documentation. Audits have not been conducted routinely and do not cover all priority cases. The integration of culture data into E-RASPRO is not yet optimal. The availability of antibiograms is not representative due to limitations in culture samples and microbiology human resources. PPRA reports have been prepared quarterly, but do not yet include complete indicators such as Days Of Therapy (DOT), IV-to-PO, and feedback audits. Conclusion: The implementation of PPRA at Hermina Jatinegara Hospital is underway but is not yet optimal. Strengthening of funding, microbiology sample capacity, routine reviews/audits, data integration, and training for all professions are needed to improve the consistency and success of PPRA implementation.

Resistensi antimikroba (AMR) telah berkembang menjadi tantangan kesehatan masyarakat global yang bersifat multidimensi, karena dampaknya tidak hanya mengancam efektivitas pengobatan infeksi, tetapi juga memengaruhi ketahanan sistem dan pendanaan kesehatan. Indonesia merespons tantangan tersebut melalui Rencana Aksi Nasional (RAN) Pengendalian Resistensi Antimikroba yang dikoordinasikan lintas kementerian dan mengadopsi pendekatan One Health. Namun, implementasi kebijakan ini masih menghadapi berbagai kendala struktural dan operasional. Penelitian ini bertujuan untuk menganalisis implementasi kebijakan pengendalian resistensi antimikroba di Indonesia melalui pendekatan One Health. Penelitian ini merupakan analisis kebijakan dengan pendekatan kualitatif dan desain studi kasus, melibatkan informan lintas sektor dari kementerian/lembaga dan mitra pembangunan, melalui wawancara mendalam dan telaah dokumen kebijakan nasional. Analisis data dilakukan menggunakan Kerangka Kebijakan FAO yang mencakup domain kesadaran, bukti, praktik, dan tata kelola, serta direfleksikan dengan hasil Joint External Evaluation (JEE). Hasil penelitian menunjukkan bahwa Indonesia telah memiliki kerangka kebijakan AMR dengan menggunakan pendekatan One Health yang komprehensif, namun implementasi strategi masih berjalan parsial. Upaya peningkatan kesadaran belum terlembaga secara sistemik, sistem bukti dan surveilans AMR belum terintegrasi lintas sektor dan wilayah, praktik pengendalian AMR menunjukkan kesenjangan antar sektor dan tingkat pelayanan, serta tata kelola lintas sektor belum memiliki daya ikat yang kuat terhadap perencanaan dan penganggaran. Penelitian ini menyimpulkan bahwa penguatan tata kelola lintas sektor, integrasi sistem berbasis bukti One Health, serta pengarusutamaan AMR dalam perencanaan pembangunan nasional dan daerah merupakan kunci untuk meningkatkan efektivitas dan keberlanjutan kebijakan pengendalian resistensi antimikroba di Indonesia hingga ke tingkat daerah.

Antimicrobial resistance (AMR) has emerged as a multidimensional global public health challenge, as its impacts extend beyond the declining effectiveness of infection treatment to threaten health system resilience and sustainable health financing. Indonesia has responded to this challenge through the National Action Plan (NAP) on Antimicrobial Resistance, coordinated across ministries and adopting a One Health approach. However, the implementation of set of policies continues to face structural and operational constraints. This study aims to analyse the implementation of AMR control policies in Indonesia through a One Health perspective. Using a qualitative policy analysis and case study design, the study involved multisectoral informants from government institutions and development partners, and employed in-depth interviews and a review of national policy documents. Data were analysed using AMR Policy Review Framework, encompassing the domains of awareness, evidence, practice, and governance, and were further examined in relation to the findings of the Joint External Evaluation (JEE). The findings indicate that Indonesia has established a comprehensive One Health–oriented AMR policy framework; however, its implementation remains fragmented. Awareness-raising efforts have not been systematically institutionalised, AMR surveillance and evidence systems remain poorly integrated across sectors and regions, AMR control practices show substantial disparities across sectors and levels of service delivery, and multisectoral governance lacks sufficient authority to influence planning and budgeting processes. This study concludes that strengthening cross-sectoral governance, integrating One Health–based evidence systems, and mainstreaming AMR into national and subnational development planning are critical to improving the effectiveness and sustainability of AMR control policies in Indonesia, including at the subnational level.

Latar Belakang: Peningkatan penggunaan antibiotik dalam beberapa dekade terakhir telah memberikan dampak besar terhadap kesehatan masyarakat global. Organisasi Kesehatan Dunia (WHO) menyebut resistensi antimikroba (Antimicrobial Resistance/AMR), berkontribusi terhadap meningkatnya angka kesakitan dan kematian, sekaligus menimbulkan beban ekonomi yang tinggi bagi sistem kesehatan. RSUD Kabupaten Bekasi sebagai rumah sakit rujukan daerah menghadapi tantangan serupa, ditandai dengan tingginya penggunaan antibiotik spektrum luas dan meningkatnya pola resistensi bakteri.  Berdasarkan antibiogram tahun 2024, angka MDRO untuk MRSA 22,22% dan ESBL 40%. Tujuan penelitian: Menilai implementasi Program Regulasi Antimikroba Sistem Prospektif (RASPRO) terhadap pola resistensi antimikroba dan efisiensi biaya penggunaan antibiotik, serta menganalisis peran tata kelola, sumber daya manusia, dan sistem monitoring evaluasi dalam mendukung program tersebut. Metode penelitian: Menggunakan desain kohort prospektif dengan pendekatan kuantitatif, membandingkan kondisi sebelum dan sesudah implementasi RASPRO. Subjek penelitian adalah pasien rawat inap yang mendapatkan terapi antibiotik di RSUD Kabupaten Bekasi dan memenuhi kriteria inklusi dalam penelitian ini. Data dianalisis melalui evaluasi pola penggunaan antibiotik (Defined Daily Dose/DDD), rasionalitas terapi berdasarkan metode Gyssens, serta analisis efisiensi biaya pembelian antibiotik. Hasil penelitian: Menunjukkan adanya perbaikan rasionalitas penggunaan antibiotik, penurunan penggunaan antibiotik spektrum luas tertentu, serta peningkatan biaya pengadaan antibiotik tertentu setelah implementasi RASPRO. Keberhasilan RASPRO juga sangat dipengaruhi oleh komitmen manajemen, kolaborasi tim PPRA, dan sistem audit prospektif yang konsisten. Kesimpulan: Implementasi RASPRO efektif dalam peningkatan rasionalitas penggunaan antibiotik namun dari segi biaya perlu adanya evaluasi faktor-faktor yang memengaruhi efisiensi dalam pembiayaan antibiotik.

Background: Antimicrobial resistance (AMR) represents a major challenge to the quality of healthcare services and hospital cost efficiency, largely driven by irrational antibiotic use. Bekasi District General Hospital implemented the Prospective Antimicrobial Regulation Program (RASPRO) as part of the Antimicrobial Resistance Control Program (PPRA) to optimize antibiotic use, reduce resistance, and improve cost efficiency. Research Objectives: Evaluate the impact of RASPRO implementation on antibiotic utilization patterns, appropriateness of therapy, antimicrobial resistance trends (antibiogram 2024), and antibiotic cost efficiency, while also analyzing the role of hospital governance and monitoring–evaluation systems in supporting program effectiveness. Research method: A prospective cohort study with a quantitative approach was conducted among hospitalized patients receiving antibiotic therapy before and after RASPRO implementation. Data were analyzed using indicators of antibiotic consumption, appropriateness of therapy assessed by the Gyssens method, antimicrobial resistance trends based on hospital antibiograms, and changes in antibiotic procurement costs. Research results:  demonstrated that RASPRO implementation improved the appropriateness of antibiotic use, reduced the utilization of broad-spectrum and restricted antibiotics, and achieved cost efficiency in antibiotic procurement. In addition, the program strengthened clinical governance through increased adherence to antibiotic use guidelines and optimization of the PPRA team’s role. Conclusion: The implementation of RASPRO has proven effective in improving the rational use of antibiotics. However, from a cost perspective, further evaluation is required to identify factors influencing the efficiency of antibiotic-related expenditures. Keywords: antimicrobial resistance; RASPRO; antibiotic stewardship; cost efficiency; hospital governance